Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study

Dhir Mashaal; Jones Heather L.; Shuai Yongli; Clifford Amber K.; Perkins Samantha; Steve Jennifer; Hogg Melissa E.; Choudry M. Haroon A.; Pingpank James F.; Holtzman Matthew P.; Zeh Herbert J. III; Bahary Nathan; Bartlett David L.; Zureikat Amer H.

首页> 外文期刊>Annals of surgical oncology >Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study

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Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study

机译：与现代全身化疗组合的肝动脉输注与单独的现代全身化疗相比，与孤立的不可切除结直肠肝转移患者单独的现代全身化疗的生存改善有关：病例对照研究

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In the era of effective modern systemic chemotherapy (CT), the role of hepatic arterial infusion of fluoxuridine (HAI-FUDR) in the treatment of isolated unresectable colorectal liver metastasis (IU-CRCLM) remains controversial. This study aimed to compare the overall survival (OS) of HAI-FUDR in combination with modern systemic CT versus modern systemic CT alone in patients with IU-CRCLM.

机译：在有效的现代全身化疗（CT）时代，肝动脉输注氟西汀（HAI-FUDR）的作用在孤立的不可切除结直肠肝转移（IU-CRCLM）的治疗中仍存在争议。本研究旨在将海福尔的整体生存（OS）与现代全身CT与现代全身CT的整体生存（OS）与IU-CRCLM患者相结合。

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《Annals of surgical oncology》 |2017年第1期|共9页
作者
Dhir Mashaal; Jones Heather L.; Shuai Yongli; Clifford Amber K.; Perkins Samantha; Steve Jennifer; Hogg Melissa E.; Choudry M. Haroon A.; Pingpank James F.; Holtzman Matthew P.; Zeh Herbert J. III; Bahary Nathan; Bartlett David L.; Zureikat Amer H.;
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Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Biostat Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Dept Med Oncol Med Ctr Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

Univ Pittsburgh Med Ctr Div Gastrointestinal Surg Oncol Pittsburgh PA 15260 USA;

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正文语种 eng
中图分类外科学;
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1. Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study [J] . Dhir Mashaal, Jones Heather L., Shuai Yongli, Annals of surgical oncology . 2017,第1期

机译：与现代全身化疗组合的肝动脉输注与单独的现代全身化疗相比，与孤立的不可切除结直肠肝转移患者单独的现代全身化疗的生存改善有关：病例对照研究
2. Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy – a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol [J] . Alice Boilève, Aline Maillard, Mathilde Wagner, BMC Cancer . 2020,第1期

机译：肝动脉输液化疗的治疗肝脏肝脏输液化疗患者肝脏直肠转移患者仍然不可切除，后系统诱导化疗后仍然不可切除 - 一种随机期II研究 - 苏丹UCGI 30 / PRODIGE 53（NCT03164655） - 研究方案 - 研究方案
3. Hepatic Arterial Infusion Chemotherapy of 5-Fluorouracil for Patients with Unresectable Liver Metastases from Colorectal Cancer Refractory to Standard Systemic Chemotherapy: A Multicenter Retrospective Study [J] . Sato Yozo, Inaba Yoshitaka, Aramaki Takeshi, Oncology: International Journal of Cancer Research and Treatment . 2020,第5期

机译：肝脏动脉输液化疗5氟尿嘧啶，对结直肠癌难以切除的肝脏转移患者标准全身化疗：多中心回顾性研究
4. PET STUDIES IN PATIENTS WITH LIVER METASTASES RECEIVING CHEMOTHERAPY [C] . A. DIMITRAKOPOULOU-STRAUSS, L.G. STRAUSS, F. OBERDORFER, Tomography in nuclear medicine . 1995

机译：接受肝转移治疗的肝转移患者的PET研究
5. Pharmacokinetics of intraarterial calcineurin inhibitor delivery to composite tissue: A study of regional and systemic advantages of intraarterial delivery of calcineurin inhibitors (cyclosporine and tacrolimus) to a vascularly isolated rabbit forelimb. [D] . Shirbacheh, Mansour V. 1999

机译：动脉钙调神经磷酸酶抑制剂向复合组织递送的药代动力学：钙调神经磷酸酶抑制剂（环孢素和他克莫司）向血管分离的兔前肢的动脉内递送的区域和全身优势的研究。
6. Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy – a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol [O] . Alice Boilève, Aline Maillard, Mathilde Wagner, 2020

机译：在全身诱导化疗后仍无法切除的仅结直肠癌转移患者中肝动脉灌注化疗的治疗强化作用–一项随机II期研究-SULTAN UCGI 30 / PRODIGE 53（NCT03164655）-研究方案
7. Prospective evaluation of 18F‐fluorodeoxyglucose positron emission tomography in patients receiving hepatic arterial and systemic chemotherapy for unresectable colorectal liver metastases [O] . Correa‐Gallego Camilo, Gavane Somali, Grewal Ravinder, 2015

机译：前瞻性评估18F-氟脱氧葡萄糖正电子发射断层显像在接受肝动脉和全身化学疗法治疗的不可切除结直肠肝转移患者中的价值

Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study

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