Rhodium(III)-catalyzed Intermolecular Unactivated Secondary C(sp(3))-H Bond Amidation Directed by 3,5-dimethylpyrazole

摘要

A Rh(III)-catalyzed intermolecular unactivated secondary C(sp(3))-H bond amidation via nitrene insertion directed by 3,5-dimethylpyrazole is reported. This procedure tolerates a broad substrate scope including chain and cyclic N-alklyamides. Notably, the directing group 3,5-dimethylpyrazole of chain N-alkylamide substrates could be easily removed via cascade intermolecular amidation and intramolecular cyclization in one-pot affording the sulfonylureas by increasing the reaction temperature.