Rhodium-Catalyzed Tandem Reaction of Isocyanides with Trifluorodiazoethane and Nucleophiles: Divergent Synthesis of Trifluoroethyl-Substituted Isoquinolines, Imidates, and Amidines

摘要

A rhodium-catalyzed tandem reaction of isocyanides with 2,2,2-trifluorodiazoethane and various nucleophiles has been developed. The protocol provides a simple and highly efficient method for the construction of trifluoroethyl-substituted isoquinolines, imidates and amidines with broad substrate scope in good to high yields. These reactions feature readily available starting materials, three-component, one-pot procedure, good to high yields, broad substrate scope, good functional group tolerance, and excellent stereoselectivity.