Immunoreactivity for SoxiO in Basaloid Neoplasms of The Skin

摘要

SOX10 is an immunohistologic determinant that is now widely used in dermatopathology, predominantly as a marker for neural and melanocytic tumors. It was first described as such by Nonaka et al in 2008.l Since then, SOX 10 expression has also been noted in tumors with myoepithelial differentiation, as well as certain cutaneous adnexal tumors such as spiradenoma and cylindroma.2"7 All of those neoplasms are basaloid tumors histologically, and the authors were interested in whether SOX10 could contribute to the differential diagnosis of those lesions. As previous publications have discussed,8'9 basaloid skin tumors of the skin can certainly be challenging diagnosti-cally. Therefore, in this study we examined SOX 10 expression in 121 neoplasms in that category, taken from our institutional archive. We also reviewed previous