Study of changes of obesity‐related inflammatory cytokines after laparoscopic sleeve gastrectomy

摘要

Abstract Background Chronic inflammation in adipose tissue may play a substantial role in the pathogenesis of obesity‐related metabolic disorders. The present study aims to evaluate the changes in adipocytokines, bile acids, fibroblast growth factor 19 (FGF‐19) and pro‐inflammatory cytokines 6?months after laparoscopic sleeve gastrectomy (LSG). Methods This prospective study included 75 obese patients with body mass index?35?kg/m 2 who underwent LSG. All patients were recruited preoperatively and followed up post‐operatively at 6?months, with laboratory assessment of their cytokines including adiponectin, leptin, resistin, bile acid, interleukin (IL)‐6, IL‐8, tumour necrosis factor‐α, monocyte chemotactic protein‐1, high‐sensitivity C‐reactive protein, plasminogen activator inhibitor‐1, serum amyloid‐A and FGF‐19. Results There were statistically highly significant changes regarding anthropometric parameters (weight, body mass index and waist‐to‐hip ratio), blood glucose and lipid profile as well as liver enzymes at 6?months post‐sleeve gastrectomy. The present study showed that the levels of serum adiponectin and FGF‐19 significantly increased at 6?months of follow‐up after surgery ( P ?0.001), while the levels of serum leptin, resistin, high‐sensitivity C‐reactive protein, plasminogen activator inhibitor‐1 and serum amyloid‐A significantly decreased at 6?months of follow‐up after surgery ( P ?0.001). There were no significant differences regarding serum bile acid, IL‐6, IL‐8, tumour necrosis factor‐α and monocyte chemotactic protein‐1. Conclusion Weight loss after LSG is associated with significant improvement of the adipokine levels towards anti‐diabetic and anti‐inflammatory profiles. Future studies should use a larger sample size and longer follow‐up periods.