If We Ask a Mouse about Biotrauma, Will It Give Us a Sensible Answer?

摘要

A CUTE respiratory distress syndrome (ARDS) is a major cause of mortality in critical care, but to date, no specific treatment exists. There is growing concern about our failure to translate from bench to bedside within the acute lung injury research community, and the crucial importance of better modeling in preclinical studies to identify targets with more predictive power is increasingly appreciated. Mechanical ventilation, while being a vital tool for support of ARDS patients, produces or worsens lung injury. This ventilator-induced lung injury (VILI) has substantive negative impact on the outcome of ARDS.