Spontaneous intracranial hypotension (SIH) is an uncommon condition characterized by the depletion of cerebro-spinal fluid (CSF) volume [3]. Enlargement of the pituitary gland may occur in SIH due to compensatory engorgement of the epidural venous plexus, which is a potential diagnostic pitfall [2]. We report a 46-year-old woman who presented with a 2-week history of headache and a partial right abducens nerve palsy. Her pituitary hormonal profiles were normal except for raised serum alpha-subunit, follicle stimulating hormone and luteinizing hormone levels, compatible with her previous oophorectomy.
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