首页> 外文期刊>American Journal of Kidney Diseases: The official journal of the National Kidney Foundation >Treatment of pregabalin toxicity by hemodialysis in a patient with kidney failure.
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Treatment of pregabalin toxicity by hemodialysis in a patient with kidney failure.

机译:肾衰竭患者血液透析治疗普瑞巴林毒性。

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摘要

Pregabalin is prescribed for neuropathic pain. We report the first case of pregabalin toxicity in a hemodialysis patient and her successful treatment with hemodialysis. The patient was a 30-year-old woman on long-term hemodialysis therapy who experienced significant myoclonus of the arms and legs when her dose of pregabalin was mistakenly increased. The drug has 3 properties that contribute to making it amenable to removal by hemodialysis: relatively low molecular weight (159.23 Da), relatively low volume of distribution (0.5 L/kg), and not bound to plasma proteins. We achieved hemodialysis clearance of 88.8 mL/min, which was associated with resolution of symptoms immediately after hemodialysis.
机译:普瑞巴林被规定为神经病疼痛。 我们在血液透析患者中报告了普瑞巴林毒性的第一种案例和她用血液透析的成功治疗。 患者是一名30岁的女性,长期血液透析治疗疗法,当她的普瑞巴林药物的剂量增加时,患有胳膊和腿部的重要肌阵挛。 该药物具有3种性能,有助于使其通过血液透析(159.23Da),相对较低的分子(0.5L / kg),不与血浆蛋白质结合而致力于去除。 我们实现了88.8毫升/分钟的血液透析清除,其与血液透析后立即症状的分辨率相关。

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