Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study

Earley Willie; Burgess Maria Victoria; Rekeda Ludmyla; Dickinson Regan; Szatmari Balazs; Nemeth Gyorgy; McIntyre Roger S.; Sachs Gary S.; Yatham Lakshmi N.

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Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study

机译：双极抑郁症的甲尿嘧啶治疗：随机双盲安慰剂控制第3期研究

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Objective: Cariprazine, a dopamine D-3/D-2 and 5-HT1A receptor partial agonist, was found to be effective in treating bipolar I depression in a previous phase 2 study. This phase 3 study further assessed the efficacy, safety, and tolerability of cariprazine in bipolar I depression.

机译：目的：甲哌嗪，多巴胺D-3 / D-2和5-HT1A受体部分激动剂，发现在前期2阶段治疗双极I抑制方面是有效的。该第3期进一步评估了甲皮针在双极I抑郁症中的疗效，安全性和耐受性。

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来源
《American journal of psychiatry》 |2019年第6期|共10页
作者
Earley Willie; Burgess Maria Victoria; Rekeda Ludmyla; Dickinson Regan; Szatmari Balazs; Nemeth Gyorgy; McIntyre Roger S.; Sachs Gary S.; Yatham Lakshmi N.;
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作者单位

Allergan Madison NJ 07940 USA;

Allergan Madison NJ 07940 USA;

Allergan Madison NJ 07940 USA;

Allergan Madison NJ 07940 USA;

Gedeon Richter Budapest Hungary;

Gedeon Richter Budapest Hungary;

Univ Hlth Network Mood Disorders Psychopharmacol Unit Toronto ON Canada;

Harvard Med Sch Dept Psychiat Boston MA 02115 USA;

Univ British Columbia Dept Psychiat Vancouver BC Canada;

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正文语种 eng
中图分类神经病学与精神病学;
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1. Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study [J] . Earley Willie, Burgess Maria Victoria, Rekeda Ludmyla, American journal of psychiatry . 2019,第6期

机译：双极抑郁症的甲尿嘧啶治疗：随机双盲安慰剂控制第3期研究
2. A double-blind, placebo-controlled study of cariprazine monotherapy for the treatment of bipolar I depression [J] . Durgam S., Lipschitz A., Guo H., Bipolar disorders. . 2015,第Suppla1期

机译：Cariprazine单药治疗双相I抑郁症的双盲，安慰剂对照研究
3. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial [J] . Jonathan B. Savitz, T. Kent Teague, Masaya Misaki, Translational psychiatry. . 2018,第1期

机译：用米诺环素和/或阿司匹林治疗双相抑郁症：适应性2×2双盲，随机，安慰剂对照的IIA期临床试验
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating the Effect of Infliximab on General Cognition in a Population of Depressed Individuals with Bipolar Disorder Type I/II [D] . Pan, Zihang. 2018

机译：一项随机，双盲，安慰剂对照的临床试验，评估英夫利昔单抗对I / II型双相情感障碍抑郁症患者总体认知的影响
6. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive 2×2 double-blind randomized placebo-controlled phase IIA clinical trial [O] . Jonathan B. Savitz, T. Kent Teague, Masaya Misaki, 2018

机译：用米诺环素和/或阿司匹林治疗双相抑郁症：适应性2×2双盲随机安慰剂对照的IIA期临床试验
7. Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study [O] . Willie Earley, Maria Victoria Burgess, Ludmyla Rekeda, 2019

机译：甲二维素治疗双极抑郁症：随机双盲安慰剂控制第3期研究

Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study

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