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Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes

机译：用完整膜的早产预杂交患者胎盘组织中胎盘组织中热休克蛋白的表达谱

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Problem > Investigating the stress response in the central cotyledon zone of placental tissue in pregnancies with <fc>PPROM</fc> , <fc>PTB</fc> , and at term in labor. </section> <section numbered="no" xml:id="aji12698-sec-0002"> <title type="main">Method of study > Gene expression of Hsp27, Hsp60, Hsp70, Hsp90, and Hsp <fc>BP</fc> 1 was compared between these particular groups. Correlation between variables including Hsp gene expression in placental tissue and the gestational age at delivery, <fc>WBC</fc> count at admission, and serum levels of <fc>CRP</fc> at admission in patients with <fc>PPROM</fc> and <fc>PTB</fc> was determined. </section> <section numbered="no" xml:id="aji12698-sec-0003"> <title type="main">Results > Both <fc>PPROM</fc> and <fc>PTB</fc> pregnancies were associated with altered Hsp gene expression profile. While <fc>PPROM</fc> and <fc>PTB</fc> always induced upregulation of Hsp27 and Hsp60, downregulation of Hsp70 and Hsp <fc>BP</fc> 1 was present entirely in patients with <fc>PPROM</fc> . Hsp <fc>BP</fc> 1 expression profile was also able to differentiate between <fc>PPROM</fc> and <fc>PTB</fc> pregnancies. The highest <fc>mRNA</fc> levels of Hsp60 and Hsp70 were detected in <fc>PTB</fc> pregnancies with elevated <fc>CRP</fc> levels at admission. Some of the examined Hsp displayed increased expression with advancing gestational age in both groups ( <fc>PPROM</fc> : Hsp27, Hsp70, and Hsp90; and <fc>PTB</fc> : Hsp27). </section> <section numbered="no" xml:id="aji12698-sec-0004"> <title type="main">Conclusion > Upregulation of Hsp27 is a common phenomenon shared between pregnancies affected with <fc>PTB</fc> and <fc>PPROM</fc> . On the other hand, downregulation of Hsp70 and Hsp <fc>BP</fc> 1 represents a unique feature of <fc>PPROM</fc> . </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“aji12698-abs-0001”> <sectioneded =“no”xml：id =“aji12698- sec-0001“> <标题类型=”main“>问题</ title> >调查用<fc> pprom </ fc>，<fc> ptb <ctb <ctb <ctb的妊娠期胎盘组织中央子叶区的应力响应/ FC>，在劳动期间。 </ p> </部分> <部分编号=“否”XML：ID =“AJI12698-SEC-0002”> <标题类型=“main”>研究方法Hsp27的基因表达式</标题> >基因表达式，在这些特定组之间比较HSP60，HSP70，HSP90和HSP <FC> BP </ FC> 1。胎盘组织中包括HSP基因表达的变量与胎儿患者的胎儿组织中的妊娠期，以及<FC> PPROM患者入院时的妊娠期，以及血清水平的血清<FC> CRP </ FC>确定</ Fc>和<Fc> PTB </ Fc>。 </ p> </ section> <secto numbyed =“no”xml：id =“aji12698-sec-0003”> <标题类型=“main”>结果</ title> >两个<fc> pprom </ FC>和<FC> PTB </ FC>妊娠与改变的HSP基因表达谱有关。虽然<FC> PPROM </ FC>和<FC> PTB </ FC>始终诱导HSP27和HSP60的上调，但HSP70和HSP <FC> BP </ FC> 1的下调完全在<FC> PPROM患者中存在</ fc>。 HSP <FC> BP </ FC> 1表达谱也能够区分<FC> PPROM </ FC>和<FC> PTB </ FC>妊娠。 HSP60和HSP70的最高<FC> mRNA </ FC>在<FC> PTB </ FC>妊娠中检测到升高的<FC> CRP </ FC>水平。一些检查的HSP显示出在两组（<FC> PPROM </ FC>：HSP27，HSP70和HSP90中的前进年龄增加的表达增加</ p> </ section> <secto numbyed =“no”xml：id =“aji12698-sec-0004”> <标题类型=“main”>结论</ title> > Hsp27的上调是一种常见的现象在受<FC> PTB </ FC>和<FC> PPROM </ FC>影响的妊娠之间共享。另一方面，HSP70和HSP <FC> BP </ FC> 1的下调代表了<FC> PPROM </ FC>的独特特征。 </ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18518/'>《AJRI: American Journal of Reproductive Immunology》</a> <b style="margin: 0 2px;">|</b><span>2017年第4期</span><b style="margin: 0 2px;">|</b><span>共1页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dvorakova Lenka&option=202" target="_blank" rel="nofollow">Dvorakova Lenka;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ivankova Katarina&option=202" target="_blank" rel="nofollow">Ivankova Katarina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krofta Ladislav&option=202" target="_blank" rel="nofollow">Krofta Ladislav;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hromadnikova Ilona&option=202" target="_blank" rel="nofollow">Hromadnikova Ilona;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Molecular Biology and Cell Pathology Third Faculty of MedicineCharles;</p> <p>Institute for the Care of Mother and Child Third Faculty of MedicineCharles UniversityPrague Czech;</p> <p>Institute for the Care of Mother and Child Third Faculty of MedicineCharles UniversityPrague Czech;</p> <p>Department of Molecular Biology and Cell Pathology Third Faculty of MedicineCharles;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1503.html" title="产科学">产科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=expression profile&option=203" rel="nofollow">expression profile;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=heat shock proteins&option=203" rel="nofollow">heat shock proteins;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=placental tissue&option=203" rel="nofollow">placental tissue;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=preterm delivery&option=203" rel="nofollow">preterm delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=real‐time PCR&option=203" rel="nofollow">real‐time PCR;</a> </p> <div class="translation"> 机译：表达谱;热休克蛋白;胎盘组织;早产;实时PCR; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022500190.html">Expression profile of heat shock proteins in placental tissues of patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dvorakova Lenka&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Dvorakova Lenka,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ivankova Katarina&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ivankova Katarina,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krofta Ladislav&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Krofta Ladislav,</a> <a href="/journal-foreign-18518/" target="_blank" rel="nofollow" class="tuijian_authcolor">AJRI: American Journal of Reproductive Immunology .</a> <span>2017</span><span>,第4期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用完整膜的早产预杂交患者胎盘组织中胎盘组织中热休克蛋白的表达谱</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704019958235.html">Expression profile of C19MC microRNAs in placental tissue of patients with preterm prelabor rupture of membranes and spontaneous preterm birth</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hromadnikova Ilona&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hromadnikova Ilona,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kotlabova Katerina&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kotlabova Katerina,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ivankova Katarina&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ivankova Katarina,</a> <a href="/journal-foreign-25231/" target="_blank" rel="nofollow" class="tuijian_authcolor">Molecular medicine reports .</a> <span>2017</span><span>,第4aPta1期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：黄热血患者胎盘组织中C19MC microRNA在膜破裂和自发早产的胎盘组织中的表达谱</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704015089769.html">Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mazaki-Tovi S&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mazaki-Tovi S,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Romero R&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Romero R,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kusanovic JP&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kusanovic JP,</a> <a href="/journal-foreign-35460/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Perinatal Medicine .</a> <span>2008</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：正常妊娠，足月自发分娩，早产和胎膜早破中羊水中的Visfatin / Pre-B细胞集落增强因子：与早产时亚临床子宫内感染有关。</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-201130_thesis/020513779274.html">Air Pollution and Preterm Premature Rupture of Membranes; 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