Examining the Relationship Between Self‐Reported Drinking and In‐Laboratory Drinking and Craving: Is There Concordance?

摘要

Background In‐laboratory drinking sessions that allow direct assessment of drinking and craving are an emerging method for testing novel pharmacotherapy compounds and behavioral interventions for alcohol use disorders. Despite wide implementation, limited evidence supports the concordance between drinking in the laboratory and in a natural setting. This study examined the relationship between self‐reports of drinking prior to and drinking and craving during an alcohol drinking paradigm (ADP). Methods Participants were adult heavy drinkers ( N ?=?64) who participated in a pharmacotherapy study. Participants completed self‐report alcohol assessments and a baseline ADP session prior to any medication administration. Alcohol craving was assessed during priming and ad lib ADP phases. Outcomes were the associations of total drinks consumed in‐laboratory and summary drinking measures for the 30?days prior to the ADP and reports of maximum drinks (past year and lifetime). Additional outcomes were the association of self‐reported drinking and alcohol craving during the ADP and the concordance between self‐report and ADP World Health Organization (WHO) drinking classifications. Results Number of drinking days, average drinks per drinking occasion, and lifetime and past‐year maximum drinks were all related to drinking in the laboratory. Heavy drinking days were not related to drinking in the laboratory but were associated with ADP craving. Alcohol craving was also associated with other measures of self‐reported drinking. There was also a significant association between WHO drinking risk classification and in‐laboratory drinking. Conclusions The observed relationships between self‐reported drinking and drinking in‐laboratory across drinking indices suggest that in‐laboratory alcohol consumption may reflect participants’ real‐world alcohol consumption, supporting the value of laboratory‐based drinking paradigms. The demonstrated relationship with self‐reported drinking and ADP alcohol craving further supports the value of such paradigms to model key drinking predictors. These results provide support for the validity of laboratory‐based paradigms to accurately reflect participants’ recent drinking levels.