Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma

Jagannath Sundar; Heffner Leonard T. Jr.; Ailawadhi Sikander; Munshi Nikhil C.; Zimmerman Todd M.; Rosenblatt Jacalyn; Lonial Sagar; Chanan-Khan Asher; Ruehle Markus; Rharbaoui Faiza; Haeder Thomas; Wartenberg-Demand Andrea; Anderson Kenneth C.

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Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma

机译：indatuximab ravtansine（bt062）单药治疗复发和/或难治性多发性骨髓瘤

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Indatuximab ravtansine (BT062) was investigated in patients with relapsed and/or refractory multiple myeloma. Indatuximab ravtansine was generally well-tolerated and showed anti-tumor activity. Based on the study results, a multi-dose schedule was selected for further clinical investigation in combination regimens.

机译：在复发和/或难治性多发性骨髓瘤的患者中研究了吲达昔单抗（BT062）。吲哚昔单抗血红素苷在耐受良好耐受并且显示出抗肿瘤活性。基于研究结果，选择多剂量计划进行组合方案进一步临床研究。

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《Clinical lymphoma, myeloma & leukemia 》 |2019年第6期| 共9页
作者
Jagannath Sundar; Heffner Leonard T. Jr.; Ailawadhi Sikander; Munshi Nikhil C.; Zimmerman Todd M.; Rosenblatt Jacalyn; Lonial Sagar; Chanan-Khan Asher; Ruehle Markus; Rharbaoui Faiza; Haeder Thomas; Wartenberg-Demand Andrea; Anderson Kenneth C.;
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作者单位

Icahn Sch Med Mt Sinai 1 Gustave Levy Pl Box 1185 New York NY 10029 USA;

Emory Univ Sch Med Dept Hematol &

Med Oncol Atlanta GA USA;

Mayo Clin Div Hematol Oncol Jacksonville FL USA;

Harvard Med Sch Dana Farber Canc Inst Jerome Lipper Multiple Myeloma Ctr Boston MA 02115 USA;

Univ Chicago Med Ctr Chicago IL 60637 USA;

Beth Israel Deaconess Med Ctr Boston MA 02215 USA;

Emory Univ Sch Med Dept Hematol &

Med Oncol Atlanta GA USA;

Mayo Clin Div Hematol Oncol Jacksonville FL USA;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Biotest AG Dreieich Germany;

Harvard Med Sch Dana Farber Canc Inst Jerome Lipper Multiple Myeloma Ctr Boston MA 02115 USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学 ;
关键词
Antibody-drug conjugate; CD138; Monoclonal antibody; Multiple-dose; Syndecan-1;

机译：抗体 - 药物缀合物;CD138;单克隆抗体;多剂量;Syndecan-1;

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专利

1. Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma [J] . Jagannath Sundar, Heffner Leonard T. Jr., Ailawadhi Sikander, Nature reviews Cancer . 2019 ,第6期

机译：indatuximab ravtansine（bt062）复发和/或难治性多发性骨髓瘤患者的单一疗法
2. Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies [J] . Kurt Sch?nfeld, Chantal Zuber, Jan Pinkas, Journal of Hematology and Oncology . 2017 ,第1期

机译：多发性骨髓瘤中的吲突兔（BT062）组合治疗：临床前研究
3. A Phase II Study of Coltuximab Ravtansine (SAR3419) Monotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia [J] . Kantarjian Hagop M., Lioure Bruno, Kim Stella K., Clinical lymphoma, myeloma & leukemia . 2016 ,第3期

机译：复发性或难治性急性淋巴细胞白血病患者中的Coltuximab Ravtansine（SAR3419）单药治疗II期研究
4. Durability of Response with Thalidomide Therapy for Relapsed Multiple Myeloma [C] . B. Myers, S.G. Jones, G. Do I an European Haematology Association . 2002

机译：耐久性耐久性与多发性骨髓瘤复发疗法
5. A Phase 1/2 Study of Ixazomib as a Replacement for Bortezomib or Carfilzomib for Multiple Myeloma Patients Recently Relapsed or Refractory to Their Last Combination Regimen Containing Either Bortezomib or Carfilzomib [D] . Forouzan, Eli. 2020

机译：Ixazomib的第1/2期作为替代品髓鞘或胭脂瘤患者的替代品的替代物，最近对含有Bortezomib或Carfilzomib的最后组合方案复发或难治
6. Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies [O] . Kurt Schönfeld, Chantal Zuber, Jan Pinkas, 2017

机译：英达妥昔单抗拉坦素（BT062）联合治疗多发性骨髓瘤：临床前研究
7. Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies [O] . Kurt Schönfeld, Chantal Zuber, Jan Pinkas, 2017

机译：英达妥昔单抗拉坦素（BT062）联合治疗多发性骨髓瘤：临床前研究

Indatuximab Ravtansine (BT062) Monotherapy in Patients With Relapsed and/or Refractory Multiple Myeloma

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