Correlations Between the Immune-related Adverse Events Spectrum and Efficacy of Anti-PD1 Immunotherapy in NSCLC Patients

Cortellini Alessio; Chiari Rita; Ricciuti Biagio; Metro Giulio; Perrone Fabiana; Tiseo Marcello; Bersanelli Melissa; Bordi Paola; Santini Daniele; Giusti Raffaele; Grassadonia Antonino; Di Marino Pietro; Tinari Nicola; De Tursi Michele; Zoratto Federica; Veltri Enzo; Malorgio Francesco; Garufi Carlo; Russano Marco; Anesi Cecilia; Zeppola Tea; Filetti Marco; Marchetti Paolo; Berardi Rossana; Rinaldi Silvia; Tudini Marianna; Silva Rosa Rita; Pireddu Annagrazia; Atzori Francesco; Iacono Daniela; Migliorino Maria Rita; Porzio Gampiero; Cannita Katia; Ficorella Corrado; Buti Sebastiano

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Correlations Between the Immune-related Adverse Events Spectrum and Efficacy of Anti-PD1 Immunotherapy in NSCLC Patients

机译：免疫相关不良事件谱与NSCLC患者抗PD1免疫疗法疗效的相关性

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The aim of this study was to investigate with a large sample size, the predictive and prognostic positive roles of occurrence of immune-related adverse events in patients with non-small-cell lung cancer treated with PD-1 inhibitors. The study confirmed that immune-related adverse events are independent predictors of higher overall response rate, longer progression-free survival and longer overall survival.

机译：本研究的目的是调查大量样本大小，对用PD-1抑制剂处理的非小细胞肺癌患者的免疫相关不良事件发生的预测和预测正面作用。该研究证实，免疫相关不良事件是较高总体反应率，无进展的生存率和更长的整体存活率的独立预测因子。

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来源
《Clinical lung cancer》 |2019年第4期|共12页
作者
Cortellini Alessio; Chiari Rita; Ricciuti Biagio; Metro Giulio; Perrone Fabiana; Tiseo Marcello; Bersanelli Melissa; Bordi Paola; Santini Daniele; Giusti Raffaele; Grassadonia Antonino; Di Marino Pietro; Tinari Nicola; De Tursi Michele; Zoratto Federica; Veltri Enzo; Malorgio Francesco; Garufi Carlo; Russano Marco; Anesi Cecilia; Zeppola Tea; Filetti Marco; Marchetti Paolo; Berardi Rossana; Rinaldi Silvia; Tudini Marianna; Silva Rosa Rita; Pireddu Annagrazia; Atzori Francesco; Iacono Daniela; Migliorino Maria Rita; Porzio Gampiero; Cannita Katia; Ficorella Corrado; Buti Sebastiano;
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作者单位

St Salvatore Hosp Med Oncol Laquila Italy;

Santa Maria Misericordia Hosp Med Oncol Perugia Italy;

Santa Maria Misericordia Hosp Med Oncol Perugia Italy;

Santa Maria Misericordia Hosp Med Oncol Perugia Italy;

Univ Hosp Parma Med Oncol Parma Italy;

Univ Hosp Parma Med Oncol Parma Italy;

Univ Hosp Parma Med Oncol Parma Italy;

Univ Hosp Parma Med Oncol Parma Italy;

Campus Biomed Univ Med Oncol Rome Italy;

Sapienza Univ Rome St Andrea Hosp Dept Clin &

Mol Med Rome Italy;

Univ G DAnnunzio Dept Med Oral &

Biotechnol Sci Chieti Italy;

SS Annunziata Hosp Clin Oncol Unit Chieti Italy;

Sapienza Univ Rome St Andrea Hosp Dept Clin &

Mol Med Rome Italy;

Sapienza Univ Rome St Andrea Hosp Dept Clin &

Mol Med Rome Italy;

Santa Maria Goretti Hosp Med Oncol Latina Italy;

Santa Maria Goretti Hosp Med Oncol Latina Italy;

Santo Spirito Hosp Med Oncol Pescara Italy;

Santo Spirito Hosp Med Oncol Pescara Italy;

Campus Biomed Univ Med Oncol Rome Italy;

Campus Biomed Univ Med Oncol Rome Italy;

Campus Biomed Univ Med Oncol Rome Italy;

Sapienza Univ Rome St Andrea Hosp Dept Clin &

Mol Med Rome Italy;

Sapienza Univ Rome St Andrea Hosp Dept Clin &

Mol Med Rome Italy;

Univ Politecn Marche Osped Riuniti Ancona Oncol Clin Ancona Italy;

Univ Politecn Marche Osped Riuniti Ancona Oncol Clin Ancona Italy;

AV2 Fabriano ASUR Marche Med Oncol Fabriano Italy;

AV2 Fabriano ASUR Marche Med Oncol Fabriano Italy;

Univ Hosp Cagliari Med Oncol Unit Cagliari Italy;

Univ Hosp Cagliari Med Oncol Unit Cagliari Italy;

St Camillo Forlanini Hosp Pulm Oncol Unit Rome Italy;

St Camillo Forlanini Hosp Pulm Oncol Unit Rome Italy;

St Salvatore Hosp Med Oncol Laquila Italy;

Univ Aquila Dept Biotechnol &

Appl Clin Sci Laquila Italy;

St Salvatore Hosp Med Oncol Laquila Italy;

Univ Hosp Parma Med Oncol Parma Italy;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Immune-related adverse events; Immunotherapy; Nivolumab; NSCLC; Pembrolizumab;

机译：免疫相关不良事件;免疫疗法;Nivolumab;NSCLC;Pembrozumab;

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专利

1. Correlations Between the Immune-related Adverse Events Spectrum and Efficacy of Anti-PD1 Immunotherapy in NSCLC Patients [J] . Cortellini Alessio, Chiari Rita, Ricciuti Biagio, Clinical lung cancer . 2019,第4期

机译：免疫相关不良事件谱与NSCLC患者抗PD1免疫疗法疗效的相关性
2. Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma [J] . Indini Alice, Di Guardo Lorenza, Cimminiello Carolina, Journal of Cancer Research and Clinical Oncology . 2019,第2期

机译：免疫相关不良事件与抗PD1免疫疗法进行转移黑素瘤的患者的提高生存相关
3. P3.04-20 Correlation of Immune-Related Adverse Events and Response from Immune Checkpoint Inhibitors in Patients with Advanced NSCLC [J] . M. Sung, A. Zer, P. Walia, Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2018,第10期

机译：P3.04-20免疫相关不良事件的相关性和免疫检查点抑制剂在高级NSCLC患者中的反应
4. Identification of Patients with Immune-related Adverse Events from Clinical Notes using Machine Learning [C] . Samir Gupta, Anas Belouali, Neil Shah, IEEE International Conference on Healthcare Informatics . 2020

机译：使用机器学习鉴定免疫相关不良事件的患者
5. Immune-Related Adverse Events in Cancer Patients Being Treated with Immune Checkpoint Inhibitors [D] . Byrne, Margaret M. 2021

机译：用免疫检查点抑制剂治疗癌症患者免疫相关不良事件
6. Safety and Efficacy of Retreating with Immunotherapy After Immune-Related Adverse Events in Patients with NSCLC [O] . Fernando C. Santini, Hira Rizvi, Andrew J. Plodkowski, -1

机译：NSCLC患者免疫相关不良事件后免疫疗法后退的安全性和有效性
7. P3.04-20 Correlation of Immune-Related Adverse Events and Response from Immune Checkpoint Inhibitors in Patients with Advanced NSCLC [O] . M. Sung, A. Zer, P. Walia, 2018

机译：P3.04-20免疫相关不良事件的相关性和免疫检查点抑制剂在高级NSCLC患者中的反应

Correlations Between the Immune-related Adverse Events Spectrum and Efficacy of Anti-PD1 Immunotherapy in NSCLC Patients

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