Association of Cytoplasmic CXCR4 With Loss of Epithelial Marker and Activation of ERK1/2 and AKT Signaling Pathways in Non-Small-Cell Lung Cancer

摘要

Identification of activated CXC-chemokine receptor 4 (CXCR4) in tumor biopsies would assist in selecting patients for potential CXCR4-targeted therapy. We analyzed 94 nonesmall-cell lung cancer (NSCLC) tissues by IHC of CXCR4 and its downstream signaling proteins as well as a mesenchymal transition (EMT) marker. We found that sub-cellular localization of CXCR4 was associated with its downstream signals and cytoplasmic CXCR4 correlated with EMT markers in NSCLC.