Fluidic and thermal properties of heliox enable the efficient generation and delivery of high concentrations of solid-phase, fine particle aerosols from viscous liquids

摘要

In patients with impaired respiratory function, heliox (80% helium, 20% oxygen) has been shown to increase the peripheral deposition of aerosols. It was hypothesized that using SUPRAER-CH, aerosols generated from viscous solutions/suspensions (4-40cP) can be delivered as solid-phase aerosols with smaller aerodynamic diameters, at higher output efficiencies and increased pay-loads using heliox than with air using SUPRAER-CA. Aerosols were generated from solutions/suspensions of 100mg/ml bovine serum albumin (BSA), 100mg/ml bovine gamma globulin, 100mg/ml polyvinylpirrolidone (PVP), 103mg/ml and 35mg/ml surfactant, and delivered at 44l/min using SUPRAER-CH with heliox and SUPRAER-CA with air. Using SUPRAER-CH with heliox, aerosols of 1.1 mu m to 3 mu m the mass median aerodynamic diameter (MMAD) were generated from the above agents at output efficiencies between 70% and 88%. Using SUPRAER-CA with air, MMAD of particles delivered from these agents ranged between 2.5 mu m and 3.6 mu m with output efficiencies between 45% and 65%. Using heliox together with a liquid flow rate of 3ml/min, the 8kDa PVP, BSA, bovine gamma globulin, and surfactant aerosols were delivered at 4.3mg/s, 3.8mg/s, 3.5mg/s, and 3.2mg/s, respectively, with output efficiencies greater than 70%. Up to 2.2g were collected at the output in 10min (i.e., 10% 8kDa PVP). These data indicate the superior utility of heliox to generate fine particle, solid-phase aerosols of proteins, antibodies, and surfactant suitable for delivery to the peripheral lung at clinically relevant doses. The high delivery rates could enable short treatment times.Copyright (c) 2019 American Association for Aerosol Research