...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced materials interfaces >Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models
【24h】

Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models

机译：Flupirtine和Diazepam组合终止已建立的状态癫痫：导致三种啮齿动物模型

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract <section xml:id="acn3497-sec-0001"> <title type="main">Objective > Status epilepticus ( <fc>SE</fc> ) is a neurological emergency requiring rapid termination of seizures. New treatment choices are needed for benzodiazepine‐refractory <fc>SE</fc> or established <fc>SE</fc> ( <fc>ESE</fc> ). Previous studies have demonstrated that the potassium‐channel opener flupirtine terminates seizures in neonatal animals. However, its effectiveness in adult <fc>ESE</fc> has not been tested. We tested whether flupirtine alone or in combination with the benzodiazepine diazepam would terminate <fc>ESE</fc> in three animal models. </section> <section xml:id="acn3497-sec-0002"> <title type="main">Methods > <fc>SE</fc> was induced by administration of lithium followed by pilocarpine, by electrical stimulation of the hippocampus or by diisopropylfluorophosphate ( <fc>DFP</fc> ) administration. Seizures were assessed by <fc>EEG</fc> recorded from the hippocampus and cortex. </section> <section xml:id="acn3497-sec-0003"> <title type="main">Results > Flupirtine alone did not terminate <fc>ESE</fc> within 60 min of administration in any of the three models of <fc>ESE</fc> . A combination of flupirtine and diazepam terminated <fc>ESE</fc> within 60 min in all the three models. The drug combination shortened the duration of <fc>ESE</fc> in all three models. Drug responsiveness was distinct between each model. </section> <section xml:id="acn3497-sec-0004"> <title type="main">Conclusion > A combination of the potassium channel opener flupirtine and diazepam is a potential therapy for <fc>ESE</fc> . </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“acn3497-abs-0001”xml：lang =“en”> <标题类型=“main”>抽象</ title> <第XML：ID =“ACN3497-SEC-0001”> <标题类型=“main”>目标</ title> > 状态癫痫症（ <FC> SE </ FC> ）是一种神经系统紧急需要快速终止癫痫发作。苯并二氮杂珠毫不死应需要新的治疗选择 <FC> SE </ FC> 或建立 <FC> SE </ FC> （ <FC> ESE </ FC> ）。以前的研究表明，钾通道开启器Flupirtine终止于新生动物中的癫痫发作。但是，它在成人的有效性 <FC> ESE </ FC> 尚未进行测试。我们测试了单独的氟吡啶或与苯二氮卓的Diazepam组合将终止 <FC> ESE </ FC> 在三个动物模型中。 </ p> </部分> <第XML：ID =“ACN3497-SEC-0002”> <标题类型=“main”>方法</ title> > <FC> SE </ FC> 通过锂施用锂诱导，然后通过汲取杀虫剂，通过电刺激海马或二异丙基氟磷酸磷酸磷酸盐（ <FC> DFP </ FC> ） 行政。癫痫发作是评估的 <FC> EEG </ FC> 从海马和皮质录制。 </ p> </部分> <第XML：ID =“ACN3497-SEC-0003”> <标题类型=“main”>结果</ title> > 单独的弗平奇没有终止 <FC> ESE </ FC> 在三种模型中的任何一个型号中的60分钟内 <FC> ESE </ FC> 。 Flupirtine和Diazepam的组合终止了 <FC> ESE </ FC> 在所有三种模型中60分钟内。药物组合缩短了持续时间 <FC> ESE </ FC> 在所有三种模型中。药物响应性在每个模型之间是不同的。 </ p> </部分> <第XML：ID =“ACN3497-SEC-0004”> <标题类型=“main”>结论</ title> > 钾通道开启器Flupirtine和Diazepam的组合是潜在的疗法 <FC> ESE </ FC> 。 </ p> </部分> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18063/'>《Advanced materials interfaces》</a> <b style="margin: 0 2px;">|</b><span>2017年第12期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Terry&option=202" target="_blank" rel="nofollow">Zhang Terry;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Todorovic Marko S.&option=202" target="_blank" rel="nofollow">Todorovic Marko S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Williamson John&option=202" target="_blank" rel="nofollow">Williamson John;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kapur Jaideep&option=202" target="_blank" rel="nofollow">Kapur Jaideep;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of NeurologyUniversity of Virginia Health Sciences CenterCharlottesville Virginia 22908;</p> <p>Department of NeurologyUniversity of Virginia Health Sciences CenterCharlottesville Virginia 22908;</p> <p>Department of NeurologyUniversity of Virginia Health Sciences CenterCharlottesville Virginia 22908;</p> <p>Department of NeurologyUniversity of Virginia Health Sciences CenterCharlottesville Virginia 22908;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204114854586.html">Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tomohiro Miyake&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tomohiro Miyake,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Toshikazu Ito&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Toshikazu Ito,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yasuto Naoi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yasuto Naoi,</a> <a href="/journal-foreign-19121/" target="_blank" rel="nofollow" class="tuijian_authcolor">Annals of Clinical and Translational Neurology .</a> <span>2017</span><span>,第12期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氟吡汀和地西epa联合终止已确立的癫痫持续状态：产生三种啮齿动物模型</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023216249.html">Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Niquet Jerome&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Niquet Jerome,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suchomelova Lucie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Suchomelova Lucie,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Thompson Kerry&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Thompson Kerry,</a> <a href="/journal-foreign-22764/" target="_blank" rel="nofollow" class="tuijian_authcolor">Epilepsia: Journal of the International League against Epilepsy .</a> <span>2017</span><span>,第7期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Brivaracetam和Brivaracetam-diazepam组合在状态癫痫实验模型中的急性和长期影响</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023216444.html">Inhibition of monoacylglycerol lipase terminates diazepam‐resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Terrone Gaetano&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Terrone Gaetano,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pauletti Alberto&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Pauletti Alberto,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Salamone Alessia&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Salamone Alessia,</a> <a href="/journal-foreign-22764/" target="_blank" rel="nofollow" class="tuijian_authcolor">Epilepsia: Journal of the International League against Epilepsy .</a> <span>2018</span><span>,第1期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：单酰基甘油脂肪酶的抑制终止于小鼠的二氮酸蛋白抗性状态，其作用通过酮饮食增强</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-257037_thesis/0705010330659.html">STATUS EPILEPTICUS: LIFE AFTER DIAZEPAM</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Simon R. Platt&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Simon R. Platt </a> <a href="/conference-foreign-257037/" target="_blank" rel="nofollow" class="tuijian_authcolor">American College of Veterinary Internal Medicine Forum .</a> <span>2008</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：状态癫痫：Diazepam后的生活</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061366595.html">Epilepsy and synaptic reorganization in models of status epilepticus and hypoxia-ischemia.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Williams, Philip Andrew.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Williams, Philip Andrew. </a> <span>2002</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：状态癫痫和缺氧缺血模型中的癫痫和突触重组。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040004990176.html">Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Terry Zhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Terry Zhang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marko S. Todorovic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Marko S. Todorovic,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=John Williamson&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">John Williamson,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氟吡汀和地西epa联合终止已确立的癫痫持续状态：产生三种啮齿动物模型</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000132685525.html">Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Terry Zhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Terry Zhang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marko S. Todorovic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Marko S. Todorovic,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=John Williamson&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">John Williamson,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Flupirtine和Diazepam组合终止已建立的状态癫痫：导致三种啮齿动物模型</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_progress-physiological-sciences_thesis/0201275158483.html">癫痫研究中常用的体外模型及啮齿类动物模型</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顾友余&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 顾友余</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈文杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈文杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=秦炯&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,秦炯</a> <span> <a href="/journal-cn-5773/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生理科学进展 </a> </span> <span> . 2019</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-rehabilitation_thesis/0201226997409.html">啮齿类脑卒中动物模型的建立</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张昕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张昕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=秦冬冬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,秦冬冬</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=尹勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,尹勇</a> <span> <a href="/journal-cn-5876/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国康复 </a> </span> <span> . 2018</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-pharmacology-toxicology_thesis/0201242148972.html">建立啮齿类酒精饮用动物模型的影响因素及研究进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘欣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘欣</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张倩倩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张倩倩</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王圣霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王圣霞</a> <span> <a href="/journal-cn-6428/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药理学与毒理学杂志 </a> </span> <span> . 2017</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-rehabilitation-medicine_thesis/0201227222051.html">卒中后抑郁啮齿类动物模型的建立与评价研究进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王倩&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王倩</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=由凤秋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,由凤秋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=熊婧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,熊婧</a> <span> <a href="/journal-cn-5878/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国康复医学杂志 </a> </span> <span> . 2014</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_experimental-laboratory-medicine_thesis/0201224675504.html">几种啮齿类动物高血脂实验动物模型的建立方法</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=丁晟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 丁晟</a> <span> <a href="/journal-cn-5828/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 实验与检验医学 </a> </span> <span> . 2013</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-290_thesis/02022366796.html">冠心病复合高血脂状态病证结合动物模型的建立与评价</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=卢令慧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 卢令慧</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LU Ling-hui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,LU Ling-hui</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=WANG Jing&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,WANG Jing</a> <span> <a href="/conference-cn-290/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第七届全国中医药博士生学术论坛 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313526264.html">大鼠杏仁核电刺激建立癫痫持续状态后颞叶癫痫模型的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=齐兆鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 齐兆鹏</a> <span> . 2010</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120110036654.html">人轮状病毒导致病理损伤和腹泻乳鼠动物模型的建立方法</a> <b>[P]</b> . <span> 中国专利： CN107550943A </span> <span> . 2018-01-09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061204311353.html">脑瘫基础上的颞叶癫痫动物模型的建立方法</a> <b>[P]</b> . <span> 中国专利： CN110269046B </span> <span> . 2021.03.26</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130422350650.html">METHODS AND COMPOSITIONS FOR TREATING STATUS EPILEPTICUS AND SEIZURES CAUSING STATUS EPILEPTICUS</a> <b>[P]</b> . <span> 外国专利： <!-- 欧洲知识产权局专利： --> EP2355818A4 </span> <span> . 2012-04-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：治疗癫痫持续状态的方法和组合物以及引起癫痫持续状态的措施 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130425916848.html">Methods and Compositions for Treating Status Epilepticus and Seizures Causing Status Epilepticus</a> <b>[P]</b> . <span> 外国专利： <!-- 美国专利： --> US2011230473A1 </span> <span> . 2011-09-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：治疗癫痫持续状态和癫痫持续状态的方法和组合物 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130424680221.html">METHODS AND COMPOSITIONS FOR TREATING STATUS EPILEPTICUS AND SEIZURES CAUSING STATUS EPILEPTICUS</a> <b>[P]</b> . <span> 外国专利： <!-- 欧洲知识产权局专利： --> EP2355818A2 </span> <span> . 2011-08-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：治疗癫痫持续状态的方法和组合物以及引起癫痫持续状态的措施 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022434590','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche"> <!-- <a href="javascript:void(0);" onclick="link_analysis('/shoppingcart/auth/list.html',this)">购物车</a>--> </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704022434590down" data-source="7," data-out-id="Q1RusvDBY2WBC8aHtlXaLCKfU1OIOpKSeCNtoS1O2Ggbtt/JywIRqN8P43rkvwAD," data-f-source-id="7" data-title="Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="0704022434590" id="docid"> <input type="hidden" value="18063" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/page.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/reference.js?v=5.8.0"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.8.0"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>