Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models

摘要

ObjectiveStatus epilepticus (SE) is a neurological emergency requiring rapid termination of seizures. New treatment choices are needed for benzodiazepine‐refractory SE or established SE (ESE). Previous studies have demonstrated that the potassium‐channel opener flupirtine terminates seizures in neonatal animals. However, its effectiveness in adult ESE has not been tested. We tested whether flupirtine alone or in combination with the benzodiazepine diazepam would terminate ESE in three animal models.