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Safety and tolerability of iobitridol in cerebral angiography: a prospective, multicenter study

机译:碘氮丙醇在脑血管造影中的安全性和耐受性:一种预期,多中心研究

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Background To date, only a few data have demonstrated the safety of iodinated contrast media for cerebral angiography. Purpose To assess contrast-related adverse events after cerebral angiography using iobitridol. Material and Methods A total of 790 patients who underwent cerebral angiography at three tertiary hospitals in the Republic of Korea between November 2017 and October 2018 were prospectively enrolled in this study. We interviewed all patients and recorded their symptoms before they left the interventional clinic after the angiography procedure and during the seven-day follow-up visit. The primary endpoints were acute (within 1 h) and delayed (1 h-7 days) adverse events associated with iobitridol injection. We also visually graded the radiographic density and image quality as secondary endpoints. Results Acute adverse events were more common than delayed adverse events. Most adverse events were either mild (96.5%) or moderate (3.45%). Among the contrast-related adverse events, feeling of warmth (59.1%) and altered taste (17.5%) were the most common acute events, whereas headache (41.9%) and allergic skin reactions (20.0%) were the most common delayed events. All cerebral angiography showed optimal density and good/excellent image quality. Conclusion The findings of this study suggest that iobitridol is a safe and effective iodinated contrast medium for use in cerebral angiography.
机译:背景技术迄今为止,只有少数数据表明了脑血管造影的碘化造影剂的安全性。目的在使用碘化醇后评估脑血管造影后的对比相关不良事件。 2017年11月至2018年11月间在大韩民国的三个高级医院接受了790名患者的790名患者,并在本研究中宣传了大韩民国。我们采访了所有患者并在血管造影程序和七天后续访问后留下介入诊所之前记录了症状。初级终点是急性(1小时内),延迟(1 H-7天)与碘硝醇注射相关的不良事件。我们还视觉上梯度将射线照相密度和图像质量作为辅助端点。结果急性不​​良事件比延迟不良事件更常见。大多数不良事件是轻度(96.5%)或中度(3.45%)。在对比相关的不良事件中,温暖的感觉(59.1%)和改变的味道(17.5%)是最常见的急性事件,而头痛(41.9%)和过敏皮肤反应(20.0%)是最常见的延迟事件。所有脑血管造影都显示出最佳的密度和良好/优异的图像质量。结论本研究的结果表明,碘化硅是一种用于脑血管造影的安全有效且有效的碘化造影剂。

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