Pancreatic neuroendocrine tumor: prediction of the tumor grade using CT findings and computerized texture analysis

摘要

Background Pancreatic neuroendocrine tumors (PNET) include heterogeneous tumors with a variable degree of inherent biologic aggressiveness represented by the histopathologic grade. Although several studies investigated the computed tomography (CT) characteristics which can predict the histopathologic grade of PNET, accurate prediction of the PNET grade by CT examination alone is still limited. Purpose To investigate the important CT findings and CT texture variables for prediction of grade of PNET. Material and Methods Sixty-six patients with pathologically confirmed PNETs (grade 1?=?45, grades 2/3?=?21) underwent preoperative contrast-enhanced CT. Two reviewers determined the presence of predefined CT findings. CT texture was also analyzed on arterial and portal phase using both two-dimensional (2D) and three-dimensional (3D) analysis. Multivariate logistic regression analysis was performed in order to identify significant predictors for tumor grade. Results Among CT findings and CT texture variables, the significant predictors for grade 2/3 tumors were an ill-defined margin (odds ratio [OR]?=?7.273), lower sphericity (OR?=?0.409) on arterial 2D analysis, higher skewness (OR?=?1.972) and lower sphericity (OR?=?0.408) on arterial 3D analysis, lower kurtosis (OR?=?0.436) and lower sphericity (OR?=?0.420) on portal 2D analysis, and a larger surface area (OR?=?2.007) and lower sphericity (OR?=?0.503) on portal 3D analysis ( P ?