Impact of histological subtype on treatment outcomes in locally advanced rectal adenocarcinoma treated with neoadjuvant chemoradiation

摘要

Colorectal cancer is the third most common cancer in men (10.0% of all cancers) and the second most common in women (9.4% of all cancers). More than half of these cases are from developed countries [1]. Various histologic subtypes of this cancer have been described. Mucinous adenocarcino-mas constitute 5-15% and signet ring cell carcinomas constitute 1% of all colorectal adenocarcinomas [2]. Each histological subtype has characteristic clinical presentation and prognosis associated with it. Several studies have shown signet cell histology to be a particularly poor prognostic marker in colorectal carcinoma [3,4]. There are very few studies reporting the impact of histological subtypes on outcomes in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiation (NACTRT). We retrospectively evaluated 205 consecutive LARC patients treated with curative intent between 1 January 2013 and 31 December 2014 at a tertiary hospital in India.