A Biomarker Combining Imaging and Neuropsychological Assessment for Tracking Early Alzheimer's Disease in Clinical Trials

Verma Nishant; Beretvas S. Natasha; Pascual Belen; Masdeu Joseph C.; Markey Mia K.

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A Biomarker Combining Imaging and Neuropsychological Assessment for Tracking Early Alzheimer's Disease in Clinical Trials

机译：临床试验中追踪早期阿尔茨海默病的成像和神经心理学评估的生物标志物

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Background: Combining optimized cognitive (Alzheimer's Disease Assessment Scale-Cognitive subscale, ADAS-Cog) and atrophy markers of Alzheimer's disease for tracking progression in clinical trials may provide greater sensitivity than currently used methods, which have yielded negative results in multiple recent trials. Furthermore, it is critical to clarify the relationship among the subcomponents yielded by cognitive and imaging testing, to address the symptomatic and anatomical variability of Alzheimer's disease.

机译：背景技术结合优化的认知（Alzheimer的疾病评估规模 - 认知次级，Alzheimer疾病的用于跟踪临床试验的进展的萎缩标记可能提供比目前使用的方法更大的敏感性，这在多个最近试验中产生了负面结果。此外，阐明认知和成像测试产生的子组件之间的关系至关重要，以解决阿尔茨海默病的症状和解剖学变异性。

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来源
《Current Alzheimer research 》 |2018年第5期| 共14页
作者
Verma Nishant; Beretvas S. Natasha; Pascual Belen; Masdeu Joseph C.; Markey Mia K.;
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作者单位

Univ Texas Austin Dept Biomed Engn 107 W Dean Keeton St Stop C0800 Austin TX 78712 USA;

Univ Texas Austin Dept Educ Psychol 1 Univ Stn D5800 Austin TX 78712 USA;

Houston Methodist Neurol Inst Nantz Natl Alzheimer Ctr 6560 Fannin St Houston TX 77030 USA;

Houston Methodist Neurol Inst Nantz Natl Alzheimer Ctr 6560 Fannin St Houston TX 77030 USA;

Univ Texas Austin Dept Biomed Engn 107 W Dean Keeton St Stop C0800 Austin TX 78712 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学 ;
关键词
Latent variable modeling; Alzheimer's disease assessment scale; Alzheimer's clinical trial; cerebral atrophy; cognitive impairment; mild cognitive impairment;

机译：潜在变量建模;阿尔茨海默病评估规模;阿尔茨海默氏症的临床试验;脑萎缩;认知障碍;轻度认知障碍;

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1. A Biomarker Combining Imaging and Neuropsychological Assessment for Tracking Early Alzheimer's Disease in Clinical Trials [J] . Verma Nishant, Beretvas S. Natasha, Pascual Belen, Current Alzheimer research . 2018 ,第5期

机译：临床试验中追踪早期阿尔茨海默病的成像和神经心理学评估的生物标志物
2. Combining Cerebrospinal Fluid Biomarkers and Neuropsychological Assessment: A Simple and Cost-Effective Algorithm to Predict the Progression from Mild Cognitive Impairment to Alzheimer's Disease Dementia [J] . Mazzeo Salvatore, Santangelo Roberto, Bernasconi Maria Paola, Journal of Alzheimer's disease: JAD . 2016 ,第4期

机译：结合脑脊液生物标记物和神经心理学评估：一种简单且具有成本效益的算法，可预测从轻度认知障碍到阿尔茨海默氏病痴呆症的进展
3. Combining Select Neuropsychological Assessment with Blood-Based Biomarkers to Detect Mild Alzheimer's Disease: A Molecular Neuropsychology Approach [J] . Edwards Melissa, Balldin Valerie Hobson, Hall James, Journal of Alzheimer's disease: JAD . 2014 ,第2期

机译：结合选择的神经心理学评估与基于血液的生物标记物来检测轻度阿尔茨海默氏病：分子神经心理学方法
4. Combining Anatomical Biomarkers with Neuropsychological Data for Multidimensional Classification of Alzheimer's Disease [C] . Q. Zhou, M. Goryawala, M. Cabrerizo, International Conference on Image Processing, Computer Vision, and Pattern Recognition . 2013

机译：将解剖学生物标志物与神经心理数据相结合，以进行阿尔茨海默病的多维分类
5. Imaging Genetics and Biomarker Variations of Clinically Diagnosed Alzheimer’s Disease [D] . ?Stage, Eddie Carl, Jr. 2020

机译：临床诊断的阿尔茨海默病的成像遗传学和生物标志物变异
6. Combining Select Neuropsychological Assessment With Blood-Based Biomarkers to detect Mild Alzheimer’s disease: A Molecular Neuropsychology approach [O] . Melissa Edwards, Valerie Hobson Balldin, James Hall, -1

机译：将特定的神经心理学评估与基于血液的生物标记物相结合以检测轻度阿尔茨海默氏病：一种分子神经心理学方法
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A Biomarker Combining Imaging and Neuropsychological Assessment for Tracking Early Alzheimer's Disease in Clinical Trials

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