Nano-Fe3O4@ZrO2-H3PO4 as an Efficient Recyclable Catalyst for the Neat Preparation of Thiazole Derivatives in Ordinary or Magnetized Water

摘要

Background: Thiazoles have been a class of important synthetic heterocyclic compoundswhich are widely used in clinical therapy. These compounds exhibited biological activities such as antitumor,antifungal, antibiotic, and antiviral properties. Also, applications such as liquid crystals and cosmeticsunscreens have been found for these important structures.Methods: The purpose of this work is to identify the most suitable condition for the synthesis of somethiazole derivatives in the presence of nano-Fe3O4@ZrO2-H3PO4 as magnetically recyclable nanocatalystthat presented as n-FZSA in the presence of the two forms of water (ordinary or magnetized) assolvent.Results: The results showed that n-FZPA exhibited high catalytic activity towards the synthesis of thiazolederivatives, with the desired products being formed in high yields. The catalyst was easily recyclableand could be reused at least three times without any discernible loss in its catalytic activity. Furthermore,this new catalytic method for the synthesis of thiazoles provides rapid access to the desiredcompounds in high yields in the presence of ordinary or magnetized water upon reflux condition followinga simple work-up procedure, and avoids the use of harmful organic solvents. Final outcomes exhibitedthat magnetized water showed better yields in shorter reaction times at the same conditions. Thismethod therefore represents a significant improvement over the methods currently available for the synthesisof thiazole derivatives.Conclusion: This new method provided some thiazole derivatives via the reaction of acyl chloride withammonium thiocyanate, amino acides and alkyl bromides catalyzed by n-FZPA in high yields overshort reaction time upon refluxing ordinary or magnetized water, following a facile work-up process.Totally, the magnetized water provided a better situation as solvent for this reaction. The catalyst is inexpensiveand easily obtained, stable and storable. Also, easy magnetic separation makes this catalystattractive in view of green chemistry and catalysis science.