A study of the physicochemical properties and structure of moxifloxacin complex with methyl-beta-cyclodextrin

摘要

The physicochemical properties and structure of moxifloxacinaEuro'methyl-beta-cyclodextrin complex have been studied by UV spectroscopy, FTIR spectroscopy, and computer simulation. The optimal conditions for the formation of the complex have been determined, and the dissociation constant of the complex in acidic media (K (dis) = (5.0 +/- 0.3) x 10(-5) De) has been obtained. It has been found that complexation significantly slows down the release of the drug in acidic media. Experimental results are in good agreement with computer simulation data. The following mechanism of complex formation has been proposed: the incorporation of the aromatic fragment of moxifloxacin into the cavity of methyl-beta-cyclodextrin is followed by additional stabilization of the complex via multiple hydrophobic interactions and hydrogen bonding.