Disaggregation of Magnesium Octa[(4'-Benzo-15-Crown-5)Oxy]Phthalocyaninate in Aqueous Micellar Solutions of Alkyltriphenylphosphonium Bromide

摘要

The behavior of magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyaninate (Mgcr(8)Pc) in aqueous micellar solutions of alkyltriphenylphosphonium bromides (C(n)TPPBs), where n = 8, 12, 14, and 16, has been studied by means of electronic absorption spectroscopy and measurements of fluorescence photophysical characteristics. Intense bands of absorption ((max) = 683 nm) and fluorescence ((max) = 694 nm) of Mgcr(8)Pc in CnTPPB micellar solutions are characterized by monoexponential decay of intensity (lifetime of 5.98-6.29 ns) and indicate that magnesium phthalocyaninate has the monomeric form. The disaggregation of Mgcr(8)Pc in the presence of C(n)TPPBs provides an opportunity to use aqueous micellar solutions containing this metallophthalocyane in photodynamic therapy, because it is the monomeric form of Mgcr(8)Pc that generates singlet oxygen molecules, which kill tumor cells.