What is the role of conventional antidepressants in the treatment of major depressive episodes with Mixed Features Specifier?

摘要

The newly introduced Mixed Features Specifier of Major Depressive Episode and Disorder (MDE/ MDD) is especially challenging in terms of pharmacological management. Prior to the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of the mixed features specifier were intradepressive hypomanic symptoms, always and only associated with bipolar disorder (BD).