Hematological, biochemical, serological, and molecular monitoring of blood donor dogs vaccinated with CaniLeish? for the prevention of Leishmaniosis

摘要

The use of systemic preventive measures in dogs living in areas with Leishmania infection is advisable, particularly in blood donors. The aim of this study was to monitor healthy blood-donor dogs immunized with the vaccine CaniLeish? by means of hematological, biochemical (serum total protein, albumin, protein electrophoresis, and C-reactive protein), serological (Speed Leish K? and IFAT), and molecular assays (qualitative PCR, qlPCR). Twenty-four dogs were monitored at (T0), second (T1), third (T2) immunizations, and 2?months (T3) after the initial immunization and at the first (T4), second (T5), and third (T6) annual booster. The results were as follows: slight hyperproteinemia (29.5%, p ?>?0.05) observed throughout the monitoring period (T0-T6); increase in C-reactive protein (46.4%, p ?