...
首页> 外文期刊>Clinical and experimental allergy : >Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study.
【24h】

Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study.

机译:孕产妇特性和益生菌补充在妊娠期间对婴幼儿敏感性的影响:双盲安慰剂对照研究。

获取原文
获取原文并翻译 | 示例

摘要

BACKGROUND: The effects of breastfeeding and probiotics on infant sensitization still remain discrepant. OBJECTIVE: To explore probable explanatory factors in infant sensitization and the protective effect of probiotics. METHODS: Altogether 171 mother-infant pairs from an ongoing placebo-controlled double-blind study with nutrition modulation by dietary counselling and probiotic supplementation were studied. Skin prick testing was done in infants at 6 and 12 months and in mothers at third trimester of pregnancy. The breast milk concentrations of cytokines TGF-beta2, soluble CD14, IFN-gamma, TNF-alpha, IL-10, IL-6, IL-4 and IL-2 were measured. RESULTS: The risk of sensitization increased in infants with allergic mothers breastfeeding over 6 months [odds ratio (OR=4.83, P=0.005)], or exclusively breastfeeding over 2.5 months (OR=3.4, P=0.018). Probiotic supplementation had a protective effect against sensitization in infants with a high hereditary risk due to maternal sensitization (OR=0.3, P=0.023). The concentration of TGF-beta2 tended to be higher in the colostrum of the mothers in the probiotic group as compared with those on placebo (probiotic/placebo ratio=1.50, P=0.073). A similar result was obtained in the subgroup of allergic mothers (probiotic/placebo ratio=1.56, P=0.094). CONCLUSION: Infants of atopic mothers, specifically when breastfed exclusively over 2.5 months or totally over 6 months, had a higher risk of sensitization at the age of 12 months. This risk could be reduced by the use of probiotics during pregnancy and lactation, partly by resulting in a beneficial composition of the breast milk.
机译:背景:母乳喂养和益生菌对婴儿敏感的影响仍然存在差异。目的:探讨婴幼儿致敏和益生菌保护作用的可能解释因素。方法:从营养咨询和益生菌补充的持续安慰剂对照的双盲研究中共有171次母婴对进行营养调制。皮肤刺测试在婴儿6和12个月和怀孕三个月的母亲中完成。测定了细胞因子TGF-Beta2,可溶性CD14,IFN-γ,TNF-α,IL-10,IL-6,IL-4和IL-2的母乳浓度。结果:患有过敏母亲母乳喂养超过6个月的婴儿(OR = 4.83,P = 0.005)]的婴儿增加风险,或者仅在2.5个月内母乳喂养(或= 3.4,p = 0.018)。益生菌补充对由于母体敏化(或= 0.3,P = 0.023)的婴儿患有高遗传风险的婴儿的敏感性的保护作用。与安慰剂(益生菌/安慰比= 1.50,P = 0.073)相比,TGF-β2的TGF-β2的浓度趋于更高。在过敏母亲的亚组中获得了类似的结果(益生菌/安慰剂比= 1.56,P = 0.094)。结论:特殊母亲的婴儿,特别是当专门超过2.5个月或超过6个月的母乳喂养时,在12个月内具有更高的敏感风险。通过在妊娠和哺乳期间使用益生菌可以减少这种风险,部分原因是通过导致母乳的有益组成。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号