Association of serum asymmetric dimethylarginine, homocysteine, and l -arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

摘要

Abstract Background Our previous study suggested that a lower l -arginine level ( Methods The concentrations of ADMA and Hcy at each of three periods in normal pregnancy were determined, and the values compared between the normal pregnancy and HDP groups. Moreover, the possible risk factors for the development of HDP also were evaluated using a multivariate logistic regression model and propensity score (PS). Results The maternal ADMA concentration was significantly elevated with advance of gestational age, while Hcy concentration was decreased from early to mid-gestation and increased from mid- to late-gestation in normal pregnancy. The maternal Hcy concentration at early gestation was significantly higher in the HDP group compared to that in the normal group. A higher maternal Hcy level (>7.2μM) in early pregnancy was independently associated with the development of HDP (PS-adjusted odds ratio=4.47, 95% confidence interval=1.51–12.82), as well as pre-pregnancy overweight [body mass index (BMI)>25kg/m 2 ], primipara status, and a lower maternal l -arginine level ( Conclusions The risk factors, such as overweight (BMI>25kg/m 2 ) before pregnancy, primipara status, higher Hcy (>7.2μM), and lower l -arginine ( Highlights ? Maternal Hcy concentration at early gestation was significantly higher in the HDP group compared to that in the normal group. ? A higher maternal Hcy level (>7.2μM) at early gestation was associated with the development of HDP. ? A combination of higher Hcy and lower l -arginine levels in early gestation might be a predictor of HDP.