The effect of combined diet and exercise intervention on body weight and the serum GPIHBP1 concentration in overweight/obese middle-aged women

摘要

Abstract Background The relationship between the effects of diet and exercise intervention and the body weight associated with the serum lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1) concentrations has not been elucidated. Methods Sixty-six overweight/obese middle aged women were assigned to the diet and exercise intervention for 4months. They were divided into 2 groups followed by the body mass index (BMI) decreased >3% ( n =41) and n =25). Serum lipids, lipoproteins and the LPL, HTGL, GPIHBP1 concentrations were determined. Results The cases in which the BMI decreased >3% exhibited significant improvement of diagnostic markers compared with the cases with Conclusions The diet and exercise intervention significantly increased the serum GPIHBP1 concentration in association with a decrease in body weight and percentage of body fat. These results suggest that GPIHBP1 is a better marker for body weight decrease than LPL. Highlights ? The cases with BMI decreased >3% exhibited improved health parameters. ? Serum LPL levels changed only partly after the diet and exercise intervention. ? Serum GPIHBP1 increased significantly after the diet and exercise intervention. ? The increased GPIHBP1 was significantly associated with decreased body weight. ? A strong association was found between serum GPIHBP1 and percentage of body fat.