Small but non-negligible discrepancy between subgroup and single CKD-EPI equation to calculate the estimated glomerular filtration rate

摘要

To the Editor The Kidney Disease: Improving Global Outcomes (KDIGO) initiative recommends that doctors calculate the estimated glomerular filtration rate (eGFR) in adults using the 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation [1]. The 2009 CKD-EPI creatinine equation has been expressed in 2 different ways, i.e., as a "subgroup equation" based on sex, creatinine concentration and race (white/other or black), and as a "single equation" that combines all of the variables into one equation [1,2]. Although the 2009 CKD-EPI creatinine equation can be expressed in these different ways, the eGFR values calculated should be the same for both. In rare cases, however, the eGFR values may differ between the 2 equations [3]. For example, when calculated using the subgroup CKD-EPI, a 48-y-old white female with a serum creatinine concentration of 1.10mg/dl (97.24 糾ol/l) has an eGFR of 60ml/min/1.73m2 [144 x (1.10/0.7)-1.209 x 0.93348], which corresponds to stage 2 CKD (GFR category),