Temperature and H2O2-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics

摘要

Temperature and H2O2 dual-responsive nanoparticles were fabricated from ferrocene modified mesoporous silica (MSN-Fc) and beta-cyclodextrin-poly(N-isopropylacrylamide) (beta-CD-PNIPAM) star-shaped polymer due to the host-guest interactions for controlled drug release. The formation and structure of beta-CD-PNIPAM@MSN-Fc composite nanoparticles was confirmed by FTIR, TGA, TEM and N-2 adsorption-desorption isotherms. The size of nanoparticles was about 100-150 nm with well-ordered mesoporous structure and PNIPAM chains coating on the surface as outer shell. The channels of MSNs and hydrophobic cavities of beta-CD were all contributed to the high drug loading capacity for nanoparticles. The release of DOX from nanoparticles was enhanced with the increase of temperature above LCST or adding H2O2 in ambient O-2. The release kinetics were studied using different models to explain drug release mechanism. Furthermore, the drug loaded composite nanoparticles exhibited excellent anti-cancer activity.