Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma

S. Saesoo; S. Sathornsumetee; P. Anekwiang; C. Treetidnipa; P. Thuwajit; S. Bunthot; W. Maneeprakorn; L. Maurizi; H. Hofmann; Ruktanonchai Uracha Rungsardthong; N. Saengkrit

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Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma

机译：与抗CD20缀合的含脂质体的脉络的表征作为中枢神经系统淋巴瘤的新型治疗剂

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?Liposome was fabricated consisting of SPIONs functionalized with anti-CD20 (RTX).

?Drug targeting and therapeutic effect was investigated in BBB model.

?The liposome can cross the BBB and exert anti-lymphoma activity in an in vitro test.

?The liposome is required as a drug carrier for effectively RTX across the BBB.

?This new delivery system has high potential for clinical translation.

Abstract

Despite advances in neuroscience cancer research during the past

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？制造脂质体，由抗CD20（RTX）官能化的散氏组成。

？调查药物靶向和治疗效果BBB模型。

？脂质体可以在体外测试中越过BBB并施加抗淋巴瘤活性。

？脂质体是有效r rx跨越BBB的rtx所需的。？此新送货系统临床翻译的高潜力。

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来源
《Colloids and Surfaces, B. Biointerfaces》 |2018年第2018期|共11页
作者
S. Saesoo; S. Sathornsumetee; P. Anekwiang; C. Treetidnipa; P. Thuwajit; S. Bunthot; W. Maneeprakorn; L. Maurizi; H. Hofmann; Ruktanonchai Uracha Rungsardthong; N. Saengkrit;
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作者单位

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

NANOTEC-Mahidol University Center of Excellence in Nanotechnology for Cancer Diagnosis and Treatment Faculty of Medicine Siriraj Hospital;

NANOTEC-Mahidol University Center of Excellence in Nanotechnology for Cancer Diagnosis and Treatment Faculty of Medicine Siriraj Hospital;

NANOTEC-Mahidol University Center of Excellence in Nanotechnology for Cancer Diagnosis and Treatment Faculty of Medicine Siriraj Hospital;

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 CNRS – Université Bourgogne Franche-Comté;

Powder Technology Laboratory Ecole Polytechnique Fédérale de Lausanne (EPFL);

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA);

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正文语种 eng
中图分类胶体化学（分散体系的物理化学）;
关键词
Primary central nervous system lymphoma (PCNSL); Blood brain barrier (BBB); Brain lymphoma; Superparamagnetic iron oxide nanoparticle (SPIONs); Rituximab; Anti-CD20; Liposome; Theranostics;

机译：原发性中枢神经系统淋巴瘤（PCNSL）;血脑屏障（BBB）;脑淋巴瘤;超顺磁性氧化铁纳米粒子（酱）;rituximab;抗CD20;脂质体;Theranostics;Theranostics;

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专利

1. Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma [J] . S. Saesoo, S. Sathornsumetee, P. Anekwiang, Colloids and Surfaces, B. Biointerfaces . 2018,第期

机译：与抗CD20缀合的含脂质体的脉络的表征作为中枢神经系统淋巴瘤的新型治疗剂
2. Imaging and Therapy with Rituximab Anti-CD20 Immunotherapy in an Animal Model of Central Nervous System Lymphoma. [J] . Muldoon LL, Lewin SJ, Dosa E, Clinical cancer research: an official journal of the American Association for Cancer Research . 2011,第8期

机译：利妥昔单抗抗CD20免疫疗法在中枢神经系统淋巴瘤动物模型中的成像和治疗。
3. Intraventricular treatment of relapsed central nervous system lymphoma with the anti-CD20 antibody rituximab | Haematologica [J] . H Schulz, H Pels, I Schmidt-Wolf, Haematologica . 2004,第6期

机译：抗CD20抗体利妥昔单抗治疗心室内复发性中枢神经系统淋巴瘤血液学
4. Mutational profile of Diffuse Large B-cell Lymphoma with central nervous system relapse: analysis of CBioPortal for Cancer Genomics database [C] . Elena Voropaeva, Olga Beresina, Tatyana Pospelova, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：弥漫性大B细胞淋巴瘤与中枢神经系统复发的突变特征：用于癌症基因组学数据库的CBioPortal分析
5. Part I. Design, synthesis and biological evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Part II. Development of novel taxoid-based drug conjugates and theranostic imaging agents towards tumor-targeted chemotherapy. [D] . Park, Bora. 2014

机译：第一部分：针对FtsZ作为抗结核药的新型2,5,6-三取代苯并咪唑的设计，合成和生物学评估。第二部分新型基于紫杉醇的药物结合物和治疗诊断剂在肿瘤靶向化疗中的应用。
6. Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma [O] . Leslie L. Muldoon, Seth J. Lewin, Edit Dósa, -1

机译：成像和利妥昔单抗的抗CD20免疫疗法治疗中枢神经系统淋巴瘤的动物模型
7. Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation - An international primary central nervous system lymphoma study group project [O] . Bromberg, Jacolien, Doorduijn, Jeanette, Illerhaus, Gerald, 2013

机译：干细胞移植时代系统性淋巴瘤的中枢神经系统复发-国际原发性中枢神经系统淋巴瘤研究组项目
8. Neurochemical Alterations in Specific Target Sites in the Central and Autonomic Nervous Systems After Exposure to Nerve Agents [R] . Kauffman, F. C. 1988

机译：暴露于神经毒剂后中枢和自主神经系统特定靶位的神经化学改变

Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma

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