Fabrication of polymer matrix-free nanocomposites based on Angelica gigas Nakai extract and their application to breast cancer therapy

摘要

Graphical abstractDisplay OmittedHighlights?Ethanol extract ofAngelica gigasNakai (AGN) nanocomposites (NCs) were prepared.?Polymer matrix-free NCs of AGN were fabricated by introducing a nanocrystal concept.?AGN NCs exhibited selective anticancer activities against breast adenocarcinoma cells.AbstractNanocomposites (NCs) based on the ethanol extract ofAngelica gigasNakai (AGN EtOH ext) were developed for breast cancer therapy. Polymer matrix-free nano-sized particles based on the extract of natural product were fabricated using a modified emulsification-solvent evaporation method. Without the use of polymer matrix, toxicity can be minimized and the clinical a