Single-unit activity of the anterior Globus pallidus internus in Tourette patients and posterior Globus pallidus internus in dystonic patients

摘要

Highlights ? Description of neuronal activity in medial-anterior Globus pallidus internus (GPia) of Tourette’s patients. ? Populations of neurons with specific firing patterns can be identified in GPi sub-territories. ? First characterisation of GPia local field potentials in Tourette’s patients. Abstract Objectives Our goal was to provide a detailed analysis of neurons’ electrophysiological activity recorded in sub-territories of Globus pallidus internus (GPi) used as Deep Brain Stimulation (DBS) targets for these clinical conditions to potentially assist electrode targeting. Methods We used intra-operative microelectrode recording during stereotactic neurosurgery to guide implantation of DBS lead. Results Units in the medial anterior part of GPi of 7 Tourette’s syndrome patients under general anesthesia were firing at mean and median rate of 32.1 and 21?Hz respectively (n?=?101), with 45% of spikes fired during bursts and 21.3 bursts per minute. In the latero-posterior part of GPi of 7 dystonic patients under local anesthesia the mean and median activity were 46.1 and 30.6?Hz respectively (n?=?27), and a mean of 21.7 bursts per minute was observed, with 30% of all spikes occurring during these bursts. Conclusion Units activity pattern – slow-regular, fast-irregular or fast-regular were present in different proportions between the two targets. Significance The electrophysiological characteristics of the medial-anterior part of GPi and its latero-posterior portion can be used to assist DBS electrode targeting and also support the refinement of pathophysiological models of Tourette’s syndrome and Dystonia.