CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African individuals

摘要

CXCR6 genetic variation was described for HIV-1-uninfected black (n = 41) and Caucasian (n = 40) South Africans. We also investigated the CXCR6 rs2234358 and rs2234355 single nucleotide polymorphisms in HIV-1 disease control in 124 HIV-1-infecteddrug-na ve black individuals [elite controllers (n = 11), viraemic controllers (VCs, n = 30), high viral load long-term nonprogressors (HVL LTNPs, n = 11) and progressors (n = 72)] compared to healthy controls (HCs; n = 232). The rs2234358-T allele was underrepresented in VCs (40.0%) compared to HCs (59%, P = 0.006), HVL LTNPs (72.7%, P = 0.012) and progressors (59%, P = 0.014). The rs2234358TT genotype was underrepresented in VCs (7%) compared to progressors (32%; OR = 6.57, P = 0.006) and HCs (35%; OR = 7.18, P = 0.001, P-bonferroni = 0.034). The rs2234355-GA genotype was overrepresented in VCs (80%) compared to HCs (50.4%; OR = 025,P= 0.003) and progressors (29.17%; OR = 0.10,P = 3.8 x 10(-5,) P-bonferroni = 0.001). The combination of rs2234355-GA in the absence of rs2234358-TT was overrepresented in VCs (80%) compared to HCs (32.6%, OR = 0.12, P = 1 x 10(-6), P-bonferroni = 3.4 x 10(-5)) and to progressors (16.7%; OR = 0.05, P< 1 X 10(-8), P-bonferroni <1 X 10(-7)). (C) 2017 Elsevier Inc. All rights reserved.