Long-term Efficacy of Tenofovir Disoproxil Fumarate Monotherapy for Multidrug-Resistant Chronic HBV infection

Lee Hye Won; Park Jun Yong; Lee Jin Woo; Yoon Ki Tae; Kim Chang Wook; Park Hana; Kim Young Seok; Paik Soon Ku; Lee Jung Il; Kim Beom Kyung; Han Kwang-Hyub; Ahn Sang Hoon

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Long-term Efficacy of Tenofovir Disoproxil Fumarate Monotherapy for Multidrug-Resistant Chronic HBV infection

机译：替诺福韦解毒富马酸盐单药治疗多药慢性HBV感染的长期疗效

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BACKGROUND & AIMS: There are no globally agreed upon treatment guidelines for patients with chronic hepatitis B virus (HBV) with multidrug resistance (MDR). We conducted a multicenter, prospective, real-world cohort study of effects of tenofovir disoproxyl fumarate (TDF) monotherapy and TDF-based combination therapy, as rescue therapy, in patients with multidrug-resistant chronic HBV infections.

机译：背景和目标：在具有多药抗性（MDR）的慢性乙型肝炎病毒（HBV）患者的治疗准则上没有全球商定。我们进行了多种，前瞻性，现实世界队列的胞藤虫富马酸骨酸（TDF）单药治疗和TDF基组合疗法，作为抢救治疗，在多药耐药慢性HBV感染患者中。

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《Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association》 |2019年第7期|共10页
作者
Lee Hye Won; Park Jun Yong; Lee Jin Woo; Yoon Ki Tae; Kim Chang Wook; Park Hana; Kim Young Seok; Paik Soon Ku; Lee Jung Il; Kim Beom Kyung; Han Kwang-Hyub; Ahn Sang Hoon;
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作者单位

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

Inha Univ Sch Med Dept Internal Med Incheon South Korea;

Pusan Natl Univ Sch Med Dept Internal Med Yangsan South Korea;

Catholic Univ Dept Internal Med Coll Med Seoul South Korea;

CHA Univ Coll Med Dept Internal Med Bundang South Korea;

Soonchunhyang Univ Coll Med Dept Internal Med Bucheon South Korea;

Yonsei Univ Dept Internal Med Wonju Coll Med Wonju South Korea;

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

Yonsei Univ Coll Med Dept Internal Med 50-1 Yonsei Ro Seoul 03722 South Korea;

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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Hepatitis B; Tenofovir; Rescue Therapy; Antiviral Resistance;

机译：乙型肝炎;替诺福韦;救援治疗;抗病毒抗性;

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1. Long-term Efficacy of Tenofovir Disoproxil Fumarate Monotherapy for Multidrug-Resistant Chronic HBV infection [J] . Lee Hye Won, Park Jun Yong, Lee Jin Woo, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2019,第7期

机译：替诺福韦解毒富马酸盐单药治疗多药慢性HBV感染的长期疗效
2. O‐043: Safety and efficacy at 1?year after switching from tenofovir disoproxil fumarate to tenofovir alafenamide in chronic HBV patients with risk factors for TDF use [J] . Journal of viral hepatitis. . 2018,第S1期

机译：O-043：在慢性HBV患者中从替诺福韦毒性富马酸莫霉素切换到Tenofovir Alafena酰胺后的慢性HBV患者的安全性和有效性
3. Efficacy and Safety of Tenofovir Alafenamide (TAF) at 96 Weeks in Chronic HBV (CHB) Patients with Risk Factors for Use of Tenofovir Disoproxil Fumarate (TDF) [J] . Buti Maria, Stepanova Tatjana, Celen Mustafa K., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：Tenofovir Alafenainide（TAF）在慢性HBV（CHB）患者使用胞多虫患者危险因素的患者96周（TDF）的患者（TDF）患者的疗效和安全性
4. Modeling and simulation for dynamics of tenofovir disoproxil fumarate anti-HBV infection therapy [C] . Xiao Chen, Jianlong Qiu, Weiqi Qin, Chinese Automation Congress . 2017

机译：替诺福韦富马酸替诺福韦抗乙肝病毒感染治疗动力学建模与仿真
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. 3-year Treatment of Tenofovir Alafenamide vs. Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China [O] . Jinlin Hou, Qin Ning, Zhongping Duan, 2021

机译：三年治疗Tenofovir Alafenainide与替诺福韦解毒富马酸莫司在中国慢性HBV感染
7. Effect of Pregnancy and Concomitant Antiretrovirals on the Pharmacokinetics of Tenofovir in Women With HIV Receiving Tenofovir Disoproxil Fumarate‐Based Antiretroviral Therapy Versus Women With HBV Receiving Tenofovir Disoproxil Fumarate Monotherapy [O] . Vera E. Bukkems, Elise J. Smolders, Gonzague Jourdain, 2020

机译：妊娠及伴随抗逆转录病毒对服用替诺福韦富马酸富马酸盐富马酸盐富马酸酯型抗逆转录病毒治疗的孕妇药代动力学患者与HBV接受Tenofovir Disoproxil Mumothate单一疗法的孕妇

Long-term Efficacy of Tenofovir Disoproxil Fumarate Monotherapy for Multidrug-Resistant Chronic HBV infection

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