Modeling and simulation for dynamics of tenofovir disoproxil fumarate anti-HBV infection therapy

摘要

This paper proposes an anti-hepatitis B virus (HBV) infection treatment model with an immune response term and an alanine aminotransferase (ALT) term. This model has five variables, which can be used to describe the evolution dynamics of the related clinical data of the chronic hepatitis B (CHB) patients. We use this model to simulate the dynamics of evolutions of serum HBV DNA levels and ALT levels of 115 CHB patients, who had been taking Tenofovir Disoproxil Fumarate (TDF) for 48 weeks. The results show that TDF has higher therapeutic efficacy and causes viral mutation at very low levels, and TDF anti-HBV infection treatment can activate the patients' two kinds of immunity to remove HBV by different ways.