Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer

Flores-Morales Amilcar; Bergmann Tobias B.; Lavallee Charlotte; Batth Tanveer S.; Lin Dong; Lerdrup Mads; Friis Stine; Bartels Anette; Kristensen Gitte; Krzyzanowska Agnieszka; Xue Hui; Fazli Ladan; Hansen Klaus H.; Roder Martin A.; Brasso Klaus; Moreira Jose M.; Bjartell Anders; Wang Yuzhuo; Olsen Jesper V; Collins Colin C.; Iglesias-Gato Diego

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer

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Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer

机译：患者衍生的异种移植物的蛋白素形表征突出了静脉内分泌分化在抗阉割前列腺癌中的作用

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Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood.

机译：目的：越来越多的抗阉割前列腺癌（CRPC）肿瘤表现出神经内分泌（NE）特征。 NE前列腺癌（NEPC）预后差，其发展知之甚少。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2019年第2期|共14页
作者
Flores-Morales Amilcar; Bergmann Tobias B.; Lavallee Charlotte; Batth Tanveer S.; Lin Dong; Lerdrup Mads; Friis Stine; Bartels Anette; Kristensen Gitte; Krzyzanowska Agnieszka; Xue Hui; Fazli Ladan; Hansen Klaus H.; Roder Martin A.; Brasso Klaus; Moreira Jose M.; Bjartell Anders; Wang Yuzhuo; Olsen Jesper V; Collins Colin C.; Iglesias-Gato Diego;
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作者单位

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Novo Nordisk Fdn Ctr Prot Res Copenhagen Denmark;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ Copenhagen Biotech Res &

Innovat Ctr Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Urol Copenhagen Prostate Canc Ctr Copenhagen Denmark;

Lund Univ Div Urol Canc Dept Translat Med Lund Sweden;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ Copenhagen Biotech Res &

Innovat Ctr Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Urol Copenhagen Prostate Canc Ctr Copenhagen Denmark;

Univ Copenhagen Rigshosp Dept Urol Copenhagen Prostate Canc Ctr Copenhagen Denmark;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

Lund Univ Div Urol Canc Dept Translat Med Lund Sweden;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ Copenhagen Fac Hlth &

Med Sci Novo Nordisk Fdn Ctr Prot Res Copenhagen Denmark;

Univ British Columbia Vancouver Prostate Ctr Vancouver BC Canada;

Univ Copenhagen Fac Hlth &

Med Sci Dept Drug Design &

Pharmacol Copenhagen Denmark;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer [J] . Flores-Morales Amilcar, Bergmann Tobias B., Lavallee Charlotte, Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第2期

机译：患者衍生的异种移植物的蛋白素形表征突出了静脉内分泌分化在抗阉割前列腺癌中的作用
2. Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer [J] . Hao Jun, Ci Xinpei, Xue Hui, European urology . 2018,第6期

机译：患者衍生的激素 - 野前列腺癌异种移植模型将生长因子受体结合蛋白10显示为促进抗阉割前列腺癌的发育的雄激素受体 - 压抑基因
3. BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2 [J] . Divya Bhagirath, Thao Ly Yang, Z. Laura Tabatabai, Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第21期

机译：BRN4是抗阉割前列腺癌中神经内分泌分化的新推动力，并选择性地用BRN2在细胞外囊中释放
4. Discovery of Human Prostate Cancer Biomarkers From a Xenograft Mouse Model and Formalin-fixed, Paraffin-embedded Prostate Cancer Tissue [C] . Hsin-Yao Tang, Lynn Beer, Tony Chang-Wong, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：从异种移植小鼠模型和福尔马林固定，石蜡嵌入前列腺癌组织中发现人前列腺癌生物标志物
5. Targeting CD133 in Androgen Receptor Indifferent, Neuroendocrine Differentiated Aggressive Variant Prostate Cancer [D] . Glumac, Paige M. 2019

机译：在雄激素受体无关，神经内分泌分化型侵袭性前列腺癌中靶向CD133
6. Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts [O] . Hung-Ming Lam, Ryan McMullin, Holly M. Nguyen, -1

机译：去势抵抗性前列腺癌患者衍生异种移植物中阿比特龙超反应性表型的表征。
7. Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer [O] . Amilcar Flores-Morales, Tobias B. Bergmann, Charlotte Lavallee, 2018

机译：患者衍生的异种移植物的蛋白素形表征突出了静脉内分泌分化在抗阉割前列腺癌中的作用
8. Neuroendocrine Differentiation in Prostate Cancer: Role of Bone Morphogenetic Protein-6 and Macrophages [R] . Kim, I. 2011

机译：前列腺癌中的神经内分泌分化：骨形态发生蛋白-6和巨噬细胞的作用

Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer

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