Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer

摘要

Cell-free DNA (cfDNA) is a unique biospecimen that contains multiple sources of DNA, including tumor, germline, fetal, and others. Clonal hematopoiesis, a process that leads to expansion of mutations in peripheral blood cells, is an additional source of DNA that adds a layer of complexity when interpreting results. Clin Cancer Res; 24(18); 4352-4. (C) 2018 AACR.