Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts

Lam Hung-Ming; McMullin Ryan; Nguyen Holly M.; Coleman Ilsa; Gormley Michael; Gulati Roman; Brown Lisha G.; Holt Sarah K.; Li Weimin; Ricci Deborah S.; Verstraeten Karin; Thomas Shibu; Mostaghel Elahe A.; Nelson Peter S.; Vessella Robert L.; Corey Eva

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Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts

机译：抗阉割前列腺癌患者衍生异种移植物中的吸管剂超声表表征

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Purpose: To identify the molecular signature associated with abiraterone acetate (AA) response and mechanisms underlying AA resistance in castration-resistant prostate cancer patient-derived xenografts (PDXs).

机译：目的：鉴定与AbiraTerone乙酸酯（AA）反应相关的分子签名和抗阉割前列腺癌患者衍生的异种移植物（PDX）的AA抗性的抗性。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2017年第9期|共12页
作者
Lam Hung-Ming; McMullin Ryan; Nguyen Holly M.; Coleman Ilsa; Gormley Michael; Gulati Roman; Brown Lisha G.; Holt Sarah K.; Li Weimin; Ricci Deborah S.; Verstraeten Karin; Thomas Shibu; Mostaghel Elahe A.; Nelson Peter S.; Vessella Robert L.; Corey Eva;
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作者单位

Univ Washington Dept Urol Seattle WA 98195 USA;

LabConnect Seattle WA USA;

Univ Washington Dept Urol Seattle WA 98195 USA;

Fred Hutchinson Canc Res Ctr 1124 Columbia St Seattle WA 98104 USA;

Janssen Res &

Dev Spring House PA USA;

Fred Hutchinson Canc Res Ctr 1124 Columbia St Seattle WA 98104 USA;

Univ Washington Dept Urol Seattle WA 98195 USA;

Univ Washington Dept Urol Seattle WA 98195 USA;

Janssen Res &

Dev Spring House PA USA;

Janssen Res &

Dev Raritan NJ USA;

Janssen Res &

Dev Beerse Belgium;

Janssen Res &

Dev Spring House PA USA;

Fred Hutchinson Canc Res Ctr 1124 Columbia St Seattle WA 98104 USA;

Fred Hutchinson Canc Res Ctr 1124 Columbia St Seattle WA 98104 USA;

Univ Washington Dept Urol Seattle WA 98195 USA;

Univ Washington Dept Urol Seattle WA 98195 USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts [J] . Lam Hung-Ming, McMullin Ryan, Nguyen Holly M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第9期

机译：抗阉割前列腺癌患者衍生异种移植物中的吸管剂超声表表征
2. Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer [J] . Hao Jun, Ci Xinpei, Xue Hui, European urology . 2018,第6期

机译：患者衍生的激素 - 野前列腺癌异种移植模型将生长因子受体结合蛋白10显示为促进抗阉割前列腺癌的发育的雄激素受体 - 压抑基因
3. Switch from abiraterone plus prednisone to abiraterone plus dexamethasone at asymptomatic PSA progression in patients with metastatic castration-resistant prostate cancer [J] . Fenioux Charlotte, Louvet Christophe, Charton Emilie, BJU international . 2019,第2期

机译：从转移性阉割的前列腺癌患者的无症状PSA进展中从Abiraaterone加上泼尼松加上Abiraatorone加上地塞米松
4. Discovery of Human Prostate Cancer Biomarkers From a Xenograft Mouse Model and Formalin-fixed, Paraffin-embedded Prostate Cancer Tissue [C] . Hsin-Yao Tang, Lynn Beer, Tony Chang-Wong, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：从异种移植小鼠模型和福尔马林固定，石蜡嵌入前列腺癌组织中发现人前列腺癌生物标志物
5. Identification and Characterization of Novel Subtypes of Castration-Resistant Prostate Cancer [D] . Tang, Fanying. 2021

机译：抗阉割前列腺癌新型亚型的鉴定与表征
6. Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts [O] . Hung-Ming Lam, Ryan McMullin, Holly M. Nguyen, -1

机译：去势抵抗性前列腺癌患者衍生异种移植物中阿比特龙超反应性表型的表征。
7. Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer [O] . Amilcar Flores-Morales, Tobias B. Bergmann, Charlotte Lavallee, 2018

机译：患者衍生的异种移植物的蛋白素形表征突出了静脉内分泌分化在抗阉割前列腺癌中的作用

Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts

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