Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor

Dosset Magalie; Godet Yann; Vauchy Charline; Beziaud Laurent; Lone Yu Chun; Sedlik Christine; Liard Christelle; Levionnois Emeline; Clerc Bertrand; Sandoval Federico; Daguindau Etienne; Wain-Hobson Simon; Tartour Eric; Langlade-Demoyen Pierre; Borg Christophe; Adotevi Olivier

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Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor

机译：基于普遍的癌症肽的治疗性疫苗破坏了对端粒酶的耐受性，并且根除已建立的肿瘤

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Purpose: To evaluate CD4(+) helper functions and antitumor effect of promiscuous universal cancer peptides (UCP) derived from telomerase reverse transcriptase (TERT).

机译：目的：评估从端粒酶逆转录酶（TERT）衍生的混杂通用癌症肽（UCP）的CD4（+）辅助功能和抗肿瘤效应。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2012年第22期|共12页
作者
Dosset Magalie; Godet Yann; Vauchy Charline; Beziaud Laurent; Lone Yu Chun; Sedlik Christine; Liard Christelle; Levionnois Emeline; Clerc Bertrand; Sandoval Federico; Daguindau Etienne; Wain-Hobson Simon; Tartour Eric; Langlade-Demoyen Pierre; Borg Christophe; Adotevi Olivier;
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INSERM UMR1098 F-25020 Besancon France;

INSERM UMR1098 F-25020 Besancon France;

INSERM UMR1098 F-25020 Besancon France;

INSERM UMR1098 F-25020 Besancon France;

Hop Paul Brousse INSERM U1014 Batiment INSERM Lavoisier Villejuif France;

INSERM U932 Inst Curie Dept Transfert F-75654 Paris 13 France;

Univ Paris 05 Hop Europeen Georges Pompidou AP HP INSERM U970 PARCC Serv Immunol Biol Paris;

INSERM UMR1098 F-25020 Besancon France;

Univ Paris 05 Hop Europeen Georges Pompidou AP HP INSERM U970 PARCC Serv Immunol Biol Paris;

INSERM UMR1098 F-25020 Besancon France;

Univ Paris 05 Hop Europeen Georges Pompidou AP HP INSERM U970 PARCC Serv Immunol Biol Paris;

INSERM UMR1098 F-25020 Besancon France;

INSERM UMR1098 F-25020 Besancon France;

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正文语种 eng
中图分类肿瘤学;
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1. Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor [J] . Dosset Magalie, Godet Yann, Vauchy Charline, Clinical cancer research: an official journal of the American Association for Cancer Research . 2012,第22期

机译：基于普遍的癌症肽的治疗性疫苗破坏了对端粒酶的耐受性，并且根除已建立的肿瘤
2. Targeting antitumor CD4 helper T cells with universal tumor-reactive helper peptides derived from telomerase for cancer vaccine [J] . AdotéviO., DossetM., GalaineJ., Human vaccines & immunotherapeutics. . 2013,第5期

机译：靶向端粒酶的通用肿瘤反应性辅助肽靶向抗肿瘤CD4辅助T细胞用于癌症疫苗
3. iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine [J] . Stéphanie Corgnac, Rachel Perret, Lianjun Zhang, Journal for ImmunoTherapy of Cancer . 2014,第1期

机译：Inkt / CD1D-抗肿瘤免疫疗法显着提高了治疗CPG /肽的癌症疫苗的疗效
4. HER1 THERAPEUTIC CANCER VACCINE: AN ACTIVE IMMUNOTHERAPY TREATMENT FOR PATIENTS WITH TUMORS EXPRESSING THE RECEPTOR OF EPIDERMAL GROWTH FACTOR (EGF-R) [C] . Eduardo Suarez, Belinda Sanchez, Zaima Mazorra, Conference on vaccine technology VI . 2018

机译：HER1癌症治疗疫苗：一种针对表皮生长因子（EGF-R）受体的肿瘤的主动免疫疗法
5. Modulating Costimulation to Break T Cell Tolerance: Potential Therapeutic Insight into Breaking Tolerance to Tumor Antigens. [D] . St. Rose, Marie-Clare. 2012

机译：调节共刺激以打破T细胞耐受性：突破肿瘤抗原耐受性的潜在治疗学见解。
6. Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BBL eradicates established tumors [O] . Rajesh K. Sharma, Kutlu G. Elpek, Esma S. Yolcu, -1

机译：作为疫苗开发的平台的平台：含有新形式的4-1bbl根除的肽的疫苗已建立肿瘤
7. Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor [O] . Magalie Dosset, Yann Godet, Charline Vauchy, 2012

机译：基于普遍的癌症肽的治疗性疫苗破坏了对端粒酶的耐受性，并且根除已建立的肿瘤

Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor

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