Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance

Stephen Z. Peeke; Kira Gritsman

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Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance

机译：用于急性高级幼苗白血病的命运：TRIB3-TWICK1相互作用促进抗性

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While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

机译：虽然急性高级幼苗白血病与全反式视黄酸（ATRA）治疗具有良好的预后，ATRA抗性是一个主要障碍。现在证明了Tribbles 3（The3）稳定Twist1，导致ATRA抵抗力。破坏该相互作用的肽导致Twist1的降解并克服ATRA抗性。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2019年第20期|共3页
作者
Stephen Z. Peeke; Kira Gritsman;
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Department of Medicine Department of Cell Biology Albert Einstein College of Medicine;

Department of Medicine Department of Cell Biology Albert Einstein College of Medicine;

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正文语种 eng
中图分类肿瘤学;
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1. Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance [J] . Stephen Z. Peeke, Kira Gritsman Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第20期

机译：用于急性高级幼苗白血病的命运：TRIB3-TWICK1相互作用促进抗性
2. TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance [J] . Jian Lin, Wu Zhang, Li-Ting Niu, Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第20期

机译：TRED3稳定高捻度1表达以促进快速APL进展和ATRA抵抗力
3. PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia [J] . Ke Li, Feng Wang, Zhao-Na Yang, Theranostics . 2020,第22期

机译：PML-RARα与TRED3的相互作用阻碍了PPARγ/ RXR功能，并在急性早幼粒细胞白血病中触发血脂血症
4. Arsenic speciation in whole blood samples from Acute Promyelocytic Leukemia (APL) patients after tetra-arsenic tetra-sulfide therapy [C] . B. Chen, W.T. Corns, P.B. Stockwell International Congress on Arsenic in the Environment . 2014

机译：在四砷四硫化物治疗后，急性早幼细胞白血病（APL）患者的全血样品中的砷形式
5. Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia [D] . Hattori Hikaru, 服部光 2019

机译：急性早幼粒细胞白血病中与维甲酸抵抗相关的新型缺失型PML-RARA突变的鉴定
6. PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia [O] . Ke Li, Feng Wang, Zhao-Na Yang, 2020

机译：PML-RARα与TRED3的相互作用阻碍了PPARγ/ RXR功能并在急性早幼粒细胞白血病中触发血脂血症
7. Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance [O] . Stephen Z. Peeke, Kira Gritsman 2019

机译：用于急性高级幼苗白血病的命运：TRIB3-TWICK1相互作用促进抗性

Twist of Fate for Acute Promyelocytic Leukemia: TRIB3–TWIST1 Interaction Promotes Resistance

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