Letter to the Editor Letter by Oda et al Regarding Article, 'Clinical Significance of High-Molecular Weight Form of Adiponection in Male Patients With Coronary Artery Disease'

摘要

Komura et al investigated the clinical significance of high-molecular weight (HMW) adiponectin with respect to risk factors for atherosclerosis and concluded that measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in patients with coronary artery disease (CAD)! However, among metabolic risk factors, fasting glucose, total cholesterol, triglycerides, high-density lipo-protein-cholesterol (HDL-C),-low-density lipoprotein-cho-lesterol (LDL-C), systolic blood pressure (SBP), and dias-tolic blood pressure (DBP) had no significant correlation with total adiponectin; and body mass index (BMI), fasting glucose, total cholesterol, HDL-C, LDL-C, SBP, and DBP had no significant correlation with HMW adiponectin in non-diabetic patients; and BMI, fasting glucose, total cholesterol, triglycerides, LDL-C, SBP, and DBP had no significant correlation with both total and HMW adiponectin in diabetic patients! Only BMI and hemoglobin (Hb) Aic had a significant correlation with total adiponectin and only HbAic had a significant correlation with HMW adiponectin in non-diabetic patients, and only HDL-C had a significant correlation with both total and HMW adiponectin in diabetic patients! Therefore, they should conclude that measurement of total and HMW adiponectin had limited usefulness in assessing metabolic risk in their male CAD patients.