Severe acute hepatitis following intravenous amiodarone : a case report and review of the literature

摘要

Background and Aims : Hepatotoxic complications of long-term oral amiodarone therapy have been well described; however, liver injury secondary to parenteral infusion of amiodarone is uncommon, potentially fatal, and poorly understood. The hepatotoxicity is thought to result from the diluent polysorbate 80 and not the amiodarone its self. Theories suggest an allergic or immunologic response leading to alterations in the hepatocellular membrane while some propose that ischemia, not a drug reaction, is truly to blame.