JAK2 mutation-negative secondary erythrocytosis in smoldering plasma cell myeloma: a case study and review of the literature.

摘要

Anemia is a common laboratory feature of plasma cell myeloma (PCM) [1]. However, the association between marked erythrocytosis and PCM has been rarely described [2-11]; most of the cases were reported prior to the JAK2 era. In this study, we report a rare case of smoldering PCM with coincidental JAK2 V617F and exon 12 mutation-negative secondary erythrocytosis. A 55-year-old Korean male presenting with an incidental finding of an increased hemoglobin level came to our hospital for further evaluation. Initial complete blood count showed a hemoglobin level of 19.5 g/dl, a platelet count of 183 X 10~9/l and a white blood cell count of 3.8 X 10~9/l, with 46% segmented neutrophils, 41% lymphocytes, 9% monocytes, 1% eosinophils, and 3% atypical lymphocytes. The biochemical profile showed protein 8.6 g/dl, albumin 3.9 g/dl and creatinine 1.1 mg/dl.