Ventricular tachyarrhythmia after adalimumab therapy in a patient with Crohn's disease

摘要

We report a case of a 19-year-old Caucasian male who was admitted to our Department in February 2010 because of the exacerbation of Crohn's Disease (CD) with a presence of an active perianal fistula. He was then qualified for the biological therapy. A routine electrocardiogram (ECG) performed at that time demonstrated a normal sinus rhythm - 75 beats/min. Subsequently, adalimumab was introduced in standard doses.After two more weeks, the patient returned to our Department to receive the third dose of adalimumab. At the time of admission the patient was asymptomatic, he was in clinical remission. However, auscultation revealed an irregularity of the cardiac rhythm. A 12-lead ECG revealed numerous premature ventricular contractions (PVC's) such as bigeminy and occasionally trigeminy.