Controlling the Outgrowth and Functions of Neural Stem Cells: The Effect of Surface Topography

Simitzi Chara; Karali Kanelina; Ranella Anthi; Stratakis Emmanuel

摘要

Abstract >Neural stem cells (NSCs) are self‐renewing cells that generate the major cell types of the central nervous system, namely neurons, astrocytes and oligodendrocytes, during embryonic development and in the adult brain. NSCs reside in a complex niche where they are exposed to a plethora of signals, including both soluble and physical signals such as compressive and shear stresses, but also discontinuities and differences in morphology of the extracellular environment, termed as topographical features. Different approaches that incorporate artificial micro‐ and nano‐scale surface topographical features have been developed aiming to recapitulate the in vivo NSC niche discontinuities and features, particularly for in vitro studies. The present review article aims at reviewing the existing body of literature on the use of artificial micro‐ and nano‐topographical features to control NSCs orientation and differentiation into neuronal and/or neuroglial lineage. The different approaches on the study of the underlying mechanism of the topography‐guided NSC responses are additionally revised and discussed. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >神经干细胞（NSCs）是自我更新的细胞，用于产生主要细胞类型的自我更新单元中枢神经系统，即神经元，星形胶质细胞和少突胶质细胞，在胚胎发育和成人脑中。 NSCs位于复杂的利基中，其中它们暴露于血清信号，包括易溶性和物理信号，例如压缩和剪切应力，但也不包括细胞外环境形态的不连续性和差异，称为地形特征。已经开发出包括人造微型和纳米级表面形貌特征的不同方法，其目的是重新携带体内NICH的不连续性和特征，特别是对于体外研究。本综述文章旨在审查使用人工微观和纳米地形特征的现有文献体系，以控制NSCs取向和分化为神经元和/或神经元素谱系。另外修订和讨论了地形引导的NSC响应的潜在机制研究的不同方法。</ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16300/'>《Chemphyschem: A European journal of chemical physics and physical chemistry 》</a> <b style="margin: 0 2px;">|</b><span>2018年第10期</span><b style="margin: 0 2px;">|</b> <span>共21页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Simitzi Chara&option=202" target="_blank" rel="nofollow">Simitzi Chara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Karali Kanelina&option=202" target="_blank" rel="nofollow">Karali Kanelina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ranella Anthi&option=202" target="_blank" rel="nofollow">Ranella Anthi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stratakis Emmanuel&option=202" target="_blank" rel="nofollow">Stratakis Emmanuel;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Foundation for Research and Technology-Hellas (FORTH)Institute of Electronic Structure and Laser (IESL)Heraklion 71003 Greece;</p> <p>Foundation for Research and Technology-Hellas (FORTH)Institute of Electronic Structure and Laser (IESL)Heraklion 71003 Greece;</p> <p>Foundation for Research and Technology-Hellas (FORTH)Institute of Electronic Structure and Laser (IESL)Heraklion 71003 Greece;</p> <p>Foundation for Research and Technology-Hellas (FORTH)Institute of Electronic Structure and Laser (IESL)Heraklion 71003 Greece;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/1186.html" title="物理化学（理论化学）、化学物理学">物理化学（理论化学）、化学物理学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=differentiation&option=203" rel="nofollow">differentiation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=micro-/nano-fabrication&option=203" rel="nofollow">micro-/nano-fabrication;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neural stem cells&option=203" rel="nofollow">neural stem cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=orientation&option=203" rel="nofollow">orientation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=topography&option=203" rel="nofollow">topography;</a> </p> <div class="translation"> 机译：分化;微/纳米制作;神经干细胞;取向;地形; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022115722.html">Controlling the Outgrowth and Functions of Neural Stem Cells: The Effect of Surface Topography</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Simitzi Chara&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Simitzi 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