The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Gal beta 1 -> 3GlcNAc beta 1 -> 3Gal beta 1 -> 4Glc)

Bandara Mithila D.; Stine Keith J.; Demchenko Alexei V

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The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Gal beta 1 -> 3GlcNAc beta 1 -> 3Gal beta 1 -> 4Glc)

机译：人乳寡糖的化学合成：乳酸 - 氮糖（GALβ1->3GLCNACβ1-> 3galβ1-> 4gLC）

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The total chemical synthesis of lacto-N-tetraose (LNT) has been completed using both convergent and linear strategies. Similarly to that of our previous HMO syntheses, the donor-acceptor protecting-leaving group combinations were found to be of paramount significance to achieving successful glycosylations and minimizing side reactions.

机译：使用两种会聚和线性策略完成了乳酸 - 氮糖（LNT）的总化学合成。与我们以前的HMO合成的类似，发现施主受体保护群组合具有最重要的意义，以实现成功的糖基，并最小化副反应。

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《Carbohydrate research》 |2019年第2019期|共7页
作者
Bandara Mithila D.; Stine Keith J.; Demchenko Alexei V;
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作者单位

Univ Missouri Dept Chem &

Biochem One Univ Blvd St Louis MO 63121 USA;

Univ Missouri Dept Chem &

Biochem One Univ Blvd St Louis MO 63121 USA;

Univ Missouri Dept Chem &

Biochem One Univ Blvd St Louis MO 63121 USA;

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正文语种 eng
中图分类有机化学;
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1. The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Gal beta 1 -> 3GlcNAc beta 1 -> 3Gal beta 1 -> 4Glc) [J] . Bandara Mithila D., Stine Keith J., Demchenko Alexei V Carbohydrate research . 2019,第期

机译：人乳寡糖的化学合成：乳酸 - 氮糖（GALβ1->3GLCNACβ1-> 3galβ1-> 4gLC）
2. Human ovarian cancer,lymphoma spleen,and bovine milk GlcNAc:#beta#1,4Gal/GalNAc transferases:two molecular species in ovarian tumor and induction of GalNAc#beta#1,4Glc synthesis by #alpha#-lactalbumin [J] . E.V.Chandrasekaran Carbohydrate research . 2001,第2期

机译：人卵巢癌，淋巴瘤脾和牛乳GlcNAc：＃beta＃1,4Gal / GalNAc转移酶：卵巢肿瘤中的两种分子种类和＃alpha＃-乳清蛋白诱导GalNAc＃beta＃1、4Glc的合成
3. High-level expression of the Neisseria meningitidis lgtA gene in Escherichia coli and characterization of the encoded N-acetylglucosaminyltransferase as a useful catalyst in the synthesis of GlcNAc beta 1-->3Gal and GalNAc beta 1-->3Gal linkages. [J] . Blixt O, van Die-I, Norberg T, Glycobiology. . 1999,第10期

机译：脑膜炎奈瑟氏球菌lgtA基因在大肠杆菌中的高水平表达以及编码的N-乙酰氨基葡萄糖基转移酶的表征，可作为合成GlcNAc beta 1-> 3Gal和GalNAc beta 1-> 3Gal连接的有用催化剂。
4. An efficient method for large-scale synthesis of stereochemically difined and conformationally constrained beta-substituted for alpha,beta-disubstituted amino acids [C] . Xuejun Tang, Vadim A.Soloshonok, Victor J.Hruby the International Peptide Symposium . 2001

机译：大规模合成立体化学差异和构象约束的α，β-二取代的氨基酸的大规模合成的有效方法
5. TGF-beta2 in Human Milk Research: Exploration of a New Field Methodology and New Findings of Biosimilar TGF-beta2 in Nonhuman Milk [D] . Sweetman, Chlöe A. 2018

机译：人乳研究中的TGF-β2：非人乳中生物仿制TGF-β2的新领域方法和新发现的探索
6. Bovine colostrum CMP-NeuAc:Gal beta(1--4)GlcNAc-R alpha(2--6)-sialyltransferase is involved in the synthesis of the terminal NeuAc alpha(2--6)GalNAc beta(1--4)GlcNAc sequence occurring on N-linked glycans of bovine milk glycoproteins. [O] . M Nemansky, D H Van den Eijnden 1992

机译：牛初乳CMP-NeuAc：Gal beta（1- 4）GlcNAc-R alpha（2- 6）-唾液酸转移酶参与末端NeuAc alpha（2- 6）GalNAc beta（1- - 4）GlcNAc序列出现在牛乳糖蛋白的N-连接的聚糖上。
7. Kinetic studies on endo-beta-galactosidase by a novel colorimetric assay and synthesis of N-acetyllactosamine-repeating oligosaccharide beta-glycosides using its transglycosylation activity [O] . Takeomi Murata, Takeshi Hattori, Satoshi Amarume, 2003

机译：用其血糖化活性进行新的比色测定和N-乙酰萘胺重复寡糖β-糖苷的合成β-半乳糖苷酶的动力学研究
8. Activation of Human Platelets by Antibodies to Thymocytes and Beta 2-Microglobulin. II. Effect of Purified Beta 2-M on the Platelet Aggregating and Lymphocytotoxic Activities of HATG and SA Beta 2mG [R] . Csako, G., Suba, E. A., Wistar, R. 1981

机译：通过针对胸腺细胞和β2-微球蛋白的抗体激活人血小板。 II。纯化的β2-m对HaTG和saβ2mG血小板聚集和淋巴细胞毒活性的影响

The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Gal beta 1 -> 3GlcNAc beta 1 -> 3Gal beta 1 -> 4Glc)

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