STUDY PROVIDES INSIGHTS ON OPTIMIZING ROLLER COMPACTION Factors such as roll gap and compaction force play an important role

摘要

AN EVALUATION carried out by Freeman Technology and Gerteis Maschinen+Processengineering AG illustrates the value of multivariate powder characterization for the optimization of dry granulation using roller compaction.Previous studies have shown how critical process parameters(CPPs)in wet granulation operations can be associated with critical quality attributes(CQAs)of a tablet [1J.This additional work demonstrates how a roller compaction process also can be managed to control granule properties that are known to impact CQAs of the final product.