A New Isochromeno[4,3-b]Chromen-7(5H)-One Derivative and Bioactive Constituents of Filipendula kiraishiensis

摘要

A new isochromeno[4,3-b]chromen-7(5H)-one derivative, 8-hydroxy-3,10-dimethoxyisochromeno [4,3-b]chromen-7(5H)-one (1), has been isolated from the aerial part of Filipendula kiraishiensis, together with seven known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (2), rutin (3), quercetin (4), and isoquercitrin (5) showed potent inhibition with IC50 values of 24.2 +/- 1.2, 18.6 +/- 1.3, 10.2 +/- 0.5, and 12.2 +/- 1.0 mu M, respectively, against LPS-induced NO generation. In addition, 8-hydroxy-3,10-dimethoxyisochromeno[4,3-b]chromen-7(5H)-one (1) exhibited anti-Dengue virus activities with IC50 value of 22.4 +/- 1.6 mu M against Dengue virus serotype 2 strain PL046.